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LAIR-1

Brief Information

Name:Leukocyte-associated immunoglobulin-like receptor 1
Target Synonym:Immunoglobulin Heavy Chain Variable Region,HLAIR1,LAIR1,Leukocyte Associated Immunoglobulin Like Receptor 1,CD305 Antigen,hLAIR1,CD305,Leukocyte-Associated Ig-Like Receptor 1
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:1
Lastest Research Phase:Phase 2 Clinical

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Part of Bioactivity data

LA1-M5254-ELISA
Mouse LAIR-1, Mouse IgG2a Fc Tag, low endotoxinMouse LAIR-1, Mouse IgG2a Fc Tag, low endotoxin (Cat. No. LA1-M5254) ELISA bioactivity

Immobilized Human Collagen I protein at 2 μg/mL (100 μL/well) can bind Mouse LAIR-1, Mouse IgG2a Fc Tag, low endotoxin (Cat. No. LA1-M5254) with a linear range of 1-10 ng/mL (QC tested).

LA1-H5252-MALS-HPLC
Human LAIR-1, Fc Tag (Cat. No. ) MALS images

The purity of Human LAIR-1, Fc Tag (Cat. No. LA1-H5252) was more than 90% and the molecular weight of this protein is around 85-105 kDa verified by SEC-MALS.

Bioactivity-ELISA
Human LAIR-1, Fc TagHuman LAIR-1, Fc Tag (Cat. No. LA1-H5252) ELISA bioactivity

Immobilized Human Collagen I protein at 2 μg/mL (100 μL/well) can bind Human LAIR-1, Fc Tag (Cat. No. LA1-H5252) with a linear range of 0.02-0.3 μg/mL (QC tested).

Synonym Name

LAIR1,CD305

Background

Leukocyte-associated immunoglobulin-like receptor-1 (LAIR-1) is constitutively expressed on the majority of human peripheral blood mononuclear leukocytes. LAIR-1 or CD305 is a transmembrane glycoprotein with a single immunoglobulin-like domain and a cytoplasmic tail containing two immune receptor tyrosine-based inhibitory motifs. LAIR-1 recruits SHP-1 and SHP-2 phosphatases upon activation, and cross-linking of the LAIR-1 antigen on natural killer (NK) cells results in strong inhibition of NK cell–mediated cytotoxicity. Functions as an inhibitory receptor that plays a constitutive negative regulatory role on cytolytic function of natural killer (NK) cells, B-cells and T-cells. Activation by Tyr phosphorylation results in recruitment and activation of the phosphatases PTPN6 and PTPN11. It also reduces the increase of intracellular calcium evoked by B-cell receptor ligation.Diseases associated with LAIR1 include Chronic Active Epstein-Barr Virus Infection and Palindromic Rheumatism.

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
NC-410 Phase 2 Clinical Nextcure Ovarian Neoplasms; Stomach Neoplasms; Colorectal Neoplasms Details
NC-410 Phase 2 Clinical Nextcure Ovarian Neoplasms; Stomach Neoplasms; Colorectal Neoplasms Details

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