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LAIR-1

LAIR-1 Protein Product ListCompare or Buy

Cat. No. Species Product Description Structure Purity Feature
LA1-M5254 Mouse Mouse LAIR1 / CD305 Protein, Mouse IgG2a Fc Tag, low endotoxin
LA1-M5254-structure
LA1-M5254-sds
LA1-C52A3 Rhesus macaque Rhesus macaque LAIR1 / CD305 Protein, Mouse IgG2a Fc Tag
LA1-C52A3-structure
LA1-C52A3-sds
LA1-H82E3 Human Biotinylated Human LAIR1 / CD305 Protein, His Tag & Avi Tag (Avitag™)
LA1-H82E3-structure
LA1-H82E3-sds
LA1-H5252 Human Human LAIR1 / CD305 Protein, Fc Tag
LA1-H5252-structure
LA1-H5252-sds
CD5-H52H1 Human Human LAIR1 / CD305 Protein, His Tag
CD5-H52H1-structure
CD5-H52H1-sds

LAIR-1 Molecule Synonym Name

LAIR1,CD305

LAIR-1 Molecule Background

Leukocyte-associated immunoglobulin-like receptor-1 (LAIR-1) is constitutively expressed on the majority of human peripheral blood mononuclear leukocytes. LAIR-1 or CD305 is a transmembrane glycoprotein with a single immunoglobulin-like domain and a cytoplasmic tail containing two immune receptor tyrosine-based inhibitory motifs. LAIR-1 recruits SHP-1 and SHP-2 phosphatases upon activation, and cross-linking of the LAIR-1 antigen on natural killer (NK) cells results in strong inhibition of NK cell¨Cmediated cytotoxicity. Functions as an inhibitory receptor that plays a constitutive negative regulatory role on cytolytic function of natural killer (NK) cells, B-cells and T-cells. Activation by Tyr phosphorylation results in recruitment and activation of the phosphatases PTPN6 and PTPN11. It also reduces the increase of intracellular calcium evoked by B-cell receptor ligation.Diseases associated with LAIR1 include Chronic Active Epstein-Barr Virus Infection and Palindromic Rheumatism.

LAIR-1 References

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