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Your Position: Home > Glycoprotein / GP (virus)

Glycoprotein / GP (virus)

Glycoprotein / GP (virus) Protein Product ListCompare or Buy

Cat. No. Species Product Description Structure Purity Feature
CMB-V52H3 HCMV Recombinant HCMV Glycoprotein B (gB), His Tag
CMB-V52H3-structure
CMB-V52H3-sds
ZE5-V5220 Ebolavirus Recombinant Ebolavirus EBOV (subtype Zaire,strain Kikwit-95) Envelope Glycoprotein 1 (GP1)
ZE5-V5220-structure
ZE5-V5220-sds
BEP-V5221 Ebolavirus Recombinant Ebolavirus (subtype Bundibugyo,strain Uganda 2007) Envelope Glycoprotein 1 (GP1)
BEP-V5221-structure
BEP-V5221-sds

Glycoprotein / GP (virus) Molecule Synonym Name

Glycoprotein GP55,Envelope glycoprotein B

Glycoprotein / GP (virus) Molecule Background

EBOV encodes seven structural proteins: nucleoprotein (NP), polymerase cofactor (VP35), (VP40), GP, transcription activator (VP30), VP24, and RNA polymerase (L). GP protein contains 160-kDa envelope-attached glycoprotein (GP) and a 110 kDa secreted glycoprotein (sGP). GP is a class I fusion protein which assembles as trimers on viral surface and plays an important role in virus entry and attachment. Mature GP is a disulfide-linked heterodimer formed by two subunits, GP1 and GP2, which are generated from the proteolytical process of GP precursor (pre-GP) by cellular furin during virus assembly . GP1 is responsible for binding to the receptor(s) on target cells. Interacts with CD209/DC-SIGN and CLEC4M/DC-SIGNR which act as cofactors for virus entry into the host cell. GP2 acts as a class I viral fusion protein. GP1,2 mediates endothelial cell activation and decreases endothelial barrier function. sGP seems to possess an anti-inflammatory activity as it can reverse the barrier-decreasing effects of TNF alpha.

Glycoprotein / GP (virus) References

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