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CD96

CD96 Protein Product ListCompare or Buy

Cat. No. Species Product Description Structure Purity Feature
TAE-H82E3 Human Biotinylated Human CD96 / TACTILE Protein, His Tag, Avi Tag (Avitag™)
TAE-H82E3-structure
TAE-H82E3-sds
TAE-H82E3-elisa_1
TAE-H52H0 Human Human CD96 / TACTILE Protein, His Tag
TAE-H52H0-structure
TAE-H52H0-sds
TAE-H52H0-elisa_1
TAE-H5252 Human Human CD96 / TACTILE Protein, Mouse IgG2a Fc Tag, low endotoxin
TAE-H5252-structure
TAE-H5252-sds
TAE-H5252-elisa_1

CD96 Molecule Synonym Name

TACTILE

CD96 Molecule Background

The progression of pancreatic cancer (PC) is significantly associated with tumor immune escape, which may be associated with nature killer (NK) cell dysfunction. CD226, CD96, and TIGIT, which share the ligand CD155, play important roles in the regulation of NK cell function. The present study was conducted to investigate the roles of these molecules in NK cells from PC patients. TIGIT and CD96 together with the co-stimulatory receptor CD226 form a pathway that is analogous to the CD28/CTLA-4 pathway, in which shared ligands and differential receptor:ligand affinities fine-tune the immune response. Although the roles of TIGIT and CD96 as immune checkpoint receptors in T cell and natural killer cell biology are just beginning to be uncovered, accumulating data support the targeting of these receptors for improving anti-tumor immune responses. A clear understanding of the immune cell populations regulated by TIGIT and CD96 is key to the design of immunotherapies that target these receptors in combination with other existing immune checkpoint blockade therapies. The dysfunction of CD96 may trigger C syndrome: A syndrome characterized by trigonocephaly, severe mental retardation, hypotonia, variable cardiac defects, redundant skin, and dysmorphic facial features, including upslanted palpebral fissures, epicanthal folds, depressed nasal bridge, and low-set, posteriorly rotated ears.

CD96 References

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