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Your Position: Home > B7-H7

B7-H7

Brief Information

Name:HERV-H LTR-associating protein 2
Target Synonym:Human endogenous retrovirus-H long terminal repeat-associating protein 2,B7-H7,B7H7
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:3
Lastest Research Phase:Phase 1 Clinical

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ACRO Quality

Part of Bioactivity data

B77-C52H3-BLI
 B7-H7 BLI

Loaded Cynomolgus B7-H7, His Tag (Cat. No. B77-C52H3) on HIS1K Biosensor, can bind Human CD28H, Fc Tag (Cat. No. CDH-H5251) with an affinity constant of 13.3 nM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).

B77-C82E9-ELISA
Biotinylated Cynomolgus B7-H7, His,AvitagBiotinylated Cynomolgus B7-H7, His,Avitag (Cat. No. B77-C82E9) ELISA bioactivity

Immobilized Biotinylated Cynomolgus B7-H7, His,Avitag (Cat. No. B77-C82E9) at 1 μg/mL (100 μL/well) on streptavidin (Cat. No. STN-N5116) precoated (0.5 μg/well) plate can bind Human CD28H, Fc Tag (Cat. No. CDH-H5251) with a linear range of 0.1-8 ng/mL (QC tested).

Synonym Name

B7-H7,HHLA2,B7 Homolog 7

Background

B7-H7 (HHLA2) is a newly identified B7 family member that regulates human T-cell functions. B7-H7 was previously known as human endogenous retrovirus-H long terminal repeat associating 2 (HHLA2) with unidentified function. Recently, B7-H7 has been identified as a specific ligand for human CD28H. The B7-H7-CD28H pathway strongly promoted CD4+ T-cell proliferation and cytokine production via an AKT-dependent signaling cascade in the presence of TCR signaling, suggesting B7-H7 comprises a new co-stimulatory pathway. The first IgV domain of B7-H7, which presumably binds to a putative receptor, shows the highest homology to other B7 family members.

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
NPX-267 NPX-267 Phase 1 Clinical NextPoint Therapeutics Inc Neoplasms Details
HBM-1020 R-1020; HBM-1020 Phase 1 Clinical Harbour Biomed Solid tumours Details

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