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Your Position: Home > PVRIG

PVRIG

Brief Information

Name:Transmembrane protein PVRIG
Target Synonym:PVRIG,PVR Related Immunoglobulin Domain Containing,CD112 Receptor,Poliovirus Receptor-Related Immunoglobulin Domain-Containing Protein,Poliovirus Receptor Related Immunoglobulin Domain Containing,Nectin-2 Receptor,C7orf15,CD112R,Transmembrane Protein PVRIG,MGC2463
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:3
Lastest Research Phase:Phase 1 Clinical

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Part of Bioactivity data

PVG-H5259-BLI
Human_FcRn_Heterodimer_Protein_Bli

Loaded Human PVRIG, Mouse IgG2a Fc Tag (Cat. No. PVG-H5259) on Protein A Biosensor, can bind Human Nectin-2, His Tag (Cat. No. PV2-H52E2) with an affinity constant of 1 μM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).

PVG-C5259-BLI
Human_FcRn_Heterodimer_Protein_Bli

Loaded Cynomolgus PVRIG, Fc Tag (Cat. No. PVG-C5259) on Protein A Biosensor, can bind Human Nectin-2, His Tag (Cat. No. PV2-H52E2) with an affinity constant of 0.44 μM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).

Synonym Name

C7orf15,C7orf15MGC138295,CD112R,MGC104322,MGC138297,MGC2463,PVRIG,CD112 receptor

Background

Human PVRIG (poliovirus receptor related immunoglobulin domain-containing protein), also known as CD112 receptor (CD112R), is an approximately 34 kDa single transmembrane protein in the poliovirus receptor-like protein (PVR) family. The CD112R gene encodes a putative single transmembrane protein, which is composed of a single extracellular IgV domain, one transmembrane domain, and a long intracellular domain. Notably, the intracellular domain of phatases. The extracellular domain sequence of human and mouse CD112R have 65.3% similarity. CD112R may act as a coinhibitory receptor that suppresses T-cell receptor-mediated signals.

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
JS-009 JS-009; TAB009 Phase 1 Clinical Shanghai Junshi Biosciences Co Ltd Solid tumours Details
SHR-2002 SHR-2002 Phase 1 Clinical Suzhou Suncadia Biopharmaceuticals Co Ltd, Shanghai Hengrui Pharmaceutical Co Ltd Neoplasms Details
COM-701 COM-701 Compugen Details
GSK-4381562 SRF-813; GSK-4381562 Phase 1 Clinical Surface Oncology Neoplasms Details
JS-009 JS-009; TAB009 Phase 1 Clinical Shanghai Junshi Biosciences Co Ltd Solid tumours Details
SHR-2002 SHR-2002 Phase 1 Clinical Suzhou Suncadia Biopharmaceuticals Co Ltd, Shanghai Hengrui Pharmaceutical Co Ltd Neoplasms Details
COM-701 COM-701 Compugen Details
GSK-4381562 SRF-813; GSK-4381562 Phase 1 Clinical Surface Oncology Neoplasms Details

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