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LIGHT

Brief Information

Name:Tumor necrosis factor superfamily member 14
Target Synonym:Tumor Necrosis Factor Superfamily Member 14,Herpesvirus Entry Mediator Ligand,TNFSF14,CD258 Antigen,Herpes Virus Entry Mediator Ligand,Tumor Necrosis Factor Ligand 1D,LTg,HVEML,LIGHT,CD258,HVEM-L,Tumor Necrosis Factor (Ligand) Superfamily, Member 14,Tumor
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:1
Lastest Research Phase:Phase 2 Clinical

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Part of Bioactivity data

LIT-H5269-Cell-based assay
Human FcRn Heterodimer Protein Cell_Base

Human LIGHT, Fc Tag (active trimer) (MALS verified) (Cat. No. LIT-H5269) induced cytotoxicity in HT-29 cells. The ED50 for this effect is 1.29-2.38 ng/mL (Routinely tested).

LIT-H5242-Cell-based assay
Human FcRn Heterodimer Protein Cell_Base

Human LIGHT, His Tag (active trimer) (MALS verified) (Cat. No. LIT-H5242) induced cytotoxicity in HT-29 cells. The ED50 for this effect is 1.11-3.87 ng/mL (Routinely tested).

LIT-H5256-BLI
Human_FcRn_Heterodimer_Protein_Bli

Loaded Human DcR3, Fc Tag (Cat. No. TNB-H5255) on AHC Biosensor, can bind Human LIGHT, Mouse IgG2a Fc Tag, low endotoxin (Cat. No. LIT-H5256) with an affinity constant of 1.64 nM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).

LIT-H5242-ELISA
Human LIGHT, His Tag (active trimer) (MALS verified)Human LIGHT, His Tag (active trimer) (MALS verified) (Cat. No. LIT-H5242) ELISA bioactivity

Immobilized Human HVEM, Fc Tag (Cat. No. HVM-H5258) at 5 μg/mL (100 μL/well) can bind Human LIGHT, His Tag (active trimer) (MALS verified) (Cat. No. LIT-H5242) with a linear range of 16-63 ng/mL (QC tested).

Customer Reviews

Synonym Name

CD258 antigen,CD258,HVEM-L,LIGHT,LTg,TNFSF14,TR2,HVEML

Background

Tumor necrosis factor ligand superfamily member 14(LIGHT) is a tumor necrosis factor (TNF) superfamily ligand that regulates T cell immune responses by signaling through the herpes virus entry mediator (HVEM) and the lymphotoxin beta receptor (LTbetaR). LIGHT has emerged as a potent initiator of T cell co-stimulation signals effecting CTL-mediated tumor rejection, allograft rejection and graft versus host disease. Constitutive expression of LIGHT leads to tissue destruction and autoimmune-like disease syndromes.

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Anti-CD258 monoclonal antibody CERC-002; MDGN-002; SAR-252067; AEVI-002 Phase 2 Clinical La Jolla Pharmaceutical Company, Kyowa Hakko Kirin Coronavirus Disease 2019 (COVID-19); Respiratory Distress Syndrome, Adult; Colitis, Ulcerative; Crohn Disease; Acute Lung Injury Details

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