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Thrombospondin-2

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Cat. No. Species Product Description Structure Purity Feature
TH2-H52H5 Human Human Thrombospondin-2 Protein, His Tag
TH2-H52H5-structure
TH2-H52H5-sds

Thrombospondin-2 Molecule Synonym Name

Thrombospondin-2, THBS2, TSP2

Thrombospondin-2 Molecule Background

Thrombospondin-2 is also known as THBS2, TSP2, TSP-2. Thrombospondin-2 (TSP2) is an anti-angiogenic matricellular protein that inhibits tumor growth and angiogenesis.  Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Ligand for CD36 mediating antiangiogenic properties. 2 SNPs in the intron region of THBS2 gene (rs6422747 and rs6422748) were associated with susceptibility of IDD. However, they were not related with severity of IDD, including the total number of degenerative disc and level of IDD. Thrombospondin 2, an important regulator of synaptogenesis in central nervous system development, was distributed in retinal macroglia cells, and its receptor ?2?-1 was in retinal neurons.  activated macroglia cells may participate in alterations of presynaptic proteins of retinal neurons following elevated hydrostatic pressure, and macroglia-derived thrombospondin 2 may modulate these changes via binding to its neuronal receptor ?2?-1.

Thrombospondin-2 References

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