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CD3 epsilon

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CD3 epsilon Part of Bioactivity data

CDN-H5253-SPR
Human_FcRn_Heterodimer_Protein_SPR

Anti-Human CD3 mAb, mouse IgG1 (Clone # SP34-2) immobilized on CM5 Chip can bind Human CD3 epsilon, Mouse IgG2a Fc Tag (Cat. No. CDN-H5253) with an affinity constant of 75.2 nM as determined in a SPR assay (Biacore T200) (Routinely tested).

CDE-C5226-SPR
Human_FcRn_Heterodimer_Protein_SPR

Cynomolgus CD3 epsilon, His Tag (Cat. No. CDE-C5226) immobilized on CM5 Chip can bind Bispecific T-cell Engager (CD3 X BCMA) with an affinity constant of 1.78 nM as determined in a SPR assay (Biacore 8K) (Routinely tested).

CD3 epsilon Molecule Synonym Name

FLJ18683,T3E,TCRE,CD3E,CD3-epsilon

CD3 epsilon Molecule Background

CD3e molecule, epsilon is also known as CD3E, is a T-cell surface single-pass type I membrane glycoprotein. CD3E contains 1 Ig-like (immunoglobulin-like) domain and 1 ITAM domain. CD3E, together with CD3-gamma, CD3-delta and CD3-zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. CD3E plays an essential role in T-cell development, and defects in CD3E gene cause severe immunodeficiency. CD3E gene has also been linked to a susceptibility to type I diabetes in women. CD3E has been shown to interact with TOP2B, CD3EAP and NCK2.

CD3 epsilon References

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