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GM-CSF R alpha

Brief Information

Name:Granulocyte-macrophage colony-stimulating factor receptor subunit alpha
Target Synonym:GM-CSF-R-alpha,GMCSFR-alpha,GMR-alpha,CD116,Colony Stimulating Factor 2 Receptor Subunit Alpha,Colony Stimulating Factor 2 Receptor, Alpha, Low-Affinity (Granulocyte-Macrophage),CSF2R,CSF2RAX,CSF2RAY,CSF2RX,CSF2RY,GM-CSF Receptor Alpha Subunit,GMCSFR,GMR,
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:1
Lastest Research Phase:Phase 3 Clinical

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By Conjugate:
Cat. No. Species Product Description Structure Purity Feature
GRA-H5255 Human Human GM-CSF R alpha Protein, Fc Tag
GRA-H5255-structure
GRA-H5255-sds
GRA-H5255-elisa_1
GRA-H52H7 Human Human GM-CSF R alpha Protein, His Tag (SPR verified)
GRA-H52H7-structure
GRA-H52H7-sds
GRA-H52H7-elisa_1
GRA-H52H7-elisa_2

Part of Bioactivity data

GRA-H52H7-SPR
Human_FcRn_Heterodimer_Protein_SPR

Human GM-CSF R alpha, His Tag (Cat. No. GRA-H52H7) captured on CM5 Chip via anti-His antibody, can bind Human GM-CSF, Tag Free (Cat. No. GMF-H4214) with an affinity constant of 16.1 nM as determined in SPR assay (Biacore T200) (QC tested).

GRA-H5255-BLI
Human_FcRn_Heterodimer_Protein_Bli

Loaded Human GM-CSF R alpha, Fc Tag (Cat. No. GRA-H5255) on Protein A Biosensor, can bind ActiveMax® Human GM-CSF, Tag Free (Cat. No. GMF-H4214) with an affinity constant of 9.21 nM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).

Synonym Name

GM-CSF R alpha,GM-CSF-R-alpha,GMCSFR-alpha,GMR-alpha,CSF2RA,CSF2R,CSF2RY,CDw116,CD116

Background

GM-CSF R alpha(Granulocyte-macrophage colony-stimulating factor receptor subunit alpha) is also known as CSF2RA, CD116, GMR-alpha. Low affinity receptor for granulocyte-macrophage colony-stimulating factor. Transduces a signal that results in the proliferation, differentiation, and functional activation of hematopoietic cells. Hereditary pulmonary alveolar proteinosis (hPAP) is a rare disorder of pulmonary surfactant accumulation and hypoxemic respiratory failure caused by mutations in CSF2RA (encoding the granulocyte/macrophage colony-stimulating factor [GM-CSF] receptor ?-chain [CD116]), which results in reduced GM-CSF-dependent pulmonary surfactant clearance by alveolar macrophages.

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Mavrilimumab CAM-3001; KPL-301; GM-CSFR; CAM3001 Phase 3 Clinical Csl Ltd Giant Cell Arteritis; Arthritis, Rheumatoid; Coronavirus Infections Details

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