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Your Position: Home > Tau-441


Brief Information

Name:Microtubule-associated protein tau
Target Synonym:MAPT,MTBT1,Paired helical filament-tau,MAPTL,Microtubule Associated Protein Tau,G Protein Beta1/Gamma2 Subunit-Interacting Factor 1,Protein Phosphatase 1, Regulatory Subunit 103,Neurofibrillary Tangle Protein,PHF-Tau,TAU,Microtubule-Associated Protein Tau, Isoform 4,Microtubule-Associated Protein Tau,PPP1R103,FTDP-17,MTBT2,DDPAC,MSTD,PPND,tau Proteins,MGC138549,FLJ31424
Number of Launched Drugs:1
Number of Drugs in Clinical Trials:31
Lastest Research Phase:Approved

Customer Reviews

Synonym Name



Tau is a microtubule-associated protein, which encodes by the MAPT gene that located on chromosome 17q21. Tau Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. Hyperphosphorylation of the tau protein (tau inclusions, pTau) can result in the self-assembly of tangles of paired helical filaments and straight filaments, which are involved in the pathogenesis of Alzheimer's disease, frontotemporal dementia, and other tauopathies. Tau-441 is known as "2N4R," "Isoform Tau-F," "Tau-4" or "Tau 441", which consisting of 441 amino acid. Tau-441 is a potential therapeutic target for pathogenesis.

Clinical and Translational Updates

Public Drug Information

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Flortaucipir F 18 F-18-AV-1451; 18F-AV-1451; T807 Approved Siemens Medical Solution Tauvid United States Alzheimer Disease Avid Radiopharmaceuticals Inc 2020-05-28 Alzheimer Disease Details

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
APN-1701 [18F]AM-PBB3; 18F-AM-PBB3; APN-1701 Phase 2 Clinical National Institute Of Radiological Sciences, Aprinoia Therapeutics Ltd Nerve Degeneration; Alzheimer Disease Details
MC-1 (Lilly) MC-1 (Lilly) Phase 1 Clinical Eli Lilly And Company Alzheimer Disease Details
11C-PBB3 11C-PBB3 Clinical National Institute Of Radiological Sciences Alzheimer Disease Details
PRX-005 PRX-005 Phase 1 Clinical Prothena Alzheimer Disease; Frontotemporal Dementia; Amyotrophic Lateral Sclerosis; Neurodegenerative Diseases Details
Protollin Phase 1 Clinical Brigham And Women'S Hospital Alzheimer Disease Details
[18F]THK-5105 [18F]THK-5105 Phase 2 Clinical Tohoku University Alzheimer Disease Details
[18F]THK-5117 [18F]THK-5117 Phase 2 Clinical Tohoku University Alzheimer Disease Details
ASN-120290 ASN-120290; ASN-561; ASN-90 Phase 1 Clinical Merck Serono Alzheimer Disease Details
Mecripyrine Hydrochloride Y-1; SCR-1693 Phase 2 Clinical Yantai Yene Pharma Co Ltd, Jiangsu Simcere Pharmaceutical Co Ltd Ganglioglioma; Alzheimer Disease Details
ReS19-T ReS19-T Phase 1 Clinical Remynd Alzheimer Disease Details
BIIB-076 NI-105; BIIB-076 Biogen Inc, Neurimmune Details
Bepranemab UCB-0107 Ucb Details
TRx-0037 TRx-0037 Taurx Pharmaceuticals Details
BEY-2153 BEY-2153 Phase 1 Clinical Beyondbio Inc Alzheimer Disease Details
Gosuranemab IPN-007; BIIB-092; huIPN-002; BMS-986168 Bristol-Myers Squibb Company, Ipierian Details
Alzheimer's disease vaccine (Axon Neuroscience) AADvac-1 Axon Biochemicals Details
Tilavonemab C2N-8E12; ABBV-8E12 C2n Diagnostics Details
BMS-241027 BMS-241027 Bristol-Myers Squibb Company Details
Leuco methylthioninium L-MTx; LMT-X; TRX-0237; Leuco-MTx; LMTM Phase 1 Clinical Taurx Pharmaceuticals Cognitive Dysfunction; Alzheimer Disease Details
E-2814 E-2814 Eisai Co Ltd Details
PNT-001 PNT-001 Phase 1 Clinical Pinteon Therapeutics Alzheimer Disease Details
Zagotenemab LY-3303560 Eli Lilly And Company Details
NPT-088 NPT-088 Proclara Biosciences Details
Buntanetap ANVS-405; ANVS-401 Phase 1 Clinical Raptor Pharmaceutical Down Syndrome; Chronic Traumatic Encephalopathy; Frontotemporal Dementia Details
ACI-35.030 ACI-35.030; ACI-35 Phase 2 Clinical Ac Immune Sa Brain Diseases; Dementia; Alzheimer Disease; Tauopathies; Cognitive Dysfunction; Central Nervous System Diseases Details
NIO-752 NIO-752 Phase 1 Clinical Novartis Pharma Ag Supranuclear Palsy, Progressive; Alzheimer Disease; Cognitive Dysfunction; Neurodegenerative Diseases Details
Posdinemab JNJ-63733657; JNJ-3657 Phase 2 Clinical Janssen Global Services Llc Cognitive Dysfunction; Alzheimer Disease; Dementia Details
APNmAb-005 APNmAb-005 Phase 1 Clinical Aprinoia Therapeutics Ltd Nerve Degeneration; Alzheimer Disease; Tauopathies Details
Lu-AF87908 Lu-AF87908; Lu-AF-87908 Phase 1 Clinical H. Lundbeck A/S Alzheimer Disease Details
APN-1607 APN-1607; 18F-PM-PBB3; 18F-APN-1607; [18F]APN-1607; [18F]MNI-958; APN-0000455; F0-PBB3; PM-PBB3; [18F]PM-PBB3 Phase 3 Clinical Aprinoia Therapeutics Ltd Supranuclear Palsy, Progressive; Alzheimer Disease; Cognitive Dysfunction Details
[18F]GTP-1 [18F]GTP-1 Phase 2 Clinical Genentech Inc Alzheimer Disease Details
Izaflortaucipir F-18 [18F]PI-2620; PI-2620; 18F-PI-2620 Phase 3 Clinical Piramal, Ac Immune Sa Hypotension; Supranuclear Palsy, Progressive; Brain Concussion; Frontotemporal Lobar Degeneration; Cognitive Dysfunction; Alzheimer Disease; Parkinson Disease Details
ISIS-814907 BIIB-080; ISIS-814907; IONIS-MAPTRx; ISIS-BIIB4Rx; IONIS-BIIB4RX Phase 2 Clinical Biogen Inc, Ionis Pharmaceuticals Inc Alzheimer Disease; Cognitive Dysfunction Details

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