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Your Position: Home > Tau-441

Tau-441

Brief Information

Name:Microtubule-associated protein tau
Target Synonym:MAPT,MTBT1,Paired helical filament-tau,MAPTL,Microtubule Associated Protein Tau,G Protein Beta1/Gamma2 Subunit-Interacting Factor 1,Protein Phosphatase 1, Regulatory Subunit 103,Neurofibrillary Tangle Protein,PHF-Tau,TAU,Microtubule-Associated Protein Tau
Number of Launched Drugs:1
Number of Drugs in Clinical Trials:29
Lastest Research Phase:Approved

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Part of Bioactivity data

TAU-H51H4-MALS-HPLC
Human Tau-441 (241-380), His Tag (Cat. No. ) MALS images

The purity of Human Tau-441 (241-380), His Tag (Cat. No. TAU-H51H4) was more than 90% and the molecular weight of this protein is around 15-23 kDa verified by SEC-MALS.

  • Background
    Tau is a microtubule-associated protein, which encodes by the MAPT gene that located on chromosome 17q21. Tau Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. Hyperphosphorylation of the tau protein (tau inclusions, pTau) can result in the self-assembly of tangles of paired helical filaments and straight filaments, which are involved in the pathogenesis of Alzheimer"s disease, frontotemporal dementia, and other tauopathies. Tau-441 is known as "2N4R," "Isoform Tau-F," "Tau-4" or "Tau 441", which consisting of 441 amino acid. Tau-441 is a potential therapeutic target for pathogenesis.
  • Clinical and Translational Updates
      
  • Please contact us via TechSupport@acrobiosystems.com if you have any question on this product.

    TAU-H51H5-MALS-HPLC
    Human Tau-441 (273-380), His Tag (Cat. No. ) MALS images

    The purity of Human Tau-441 (273-380), His Tag (Cat. No. TAU-H51H5) was more than 90% and the molecular weight of this protein is around 12-18 kDa verified by SEC-MALS.

Customer Reviews

Synonym Name

DDPAC,FTDP-17,MAPT,MSTD,MTBT1,Tau,PHF-tau,TAU

Background

Tau is a microtubule-associated protein, which encodes by the MAPT gene that located on chromosome 17q21. Tau Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. Hyperphosphorylation of the tau protein (tau inclusions, pTau) can result in the self-assembly of tangles of paired helical filaments and straight filaments, which are involved in the pathogenesis of Alzheimer's disease, frontotemporal dementia, and other tauopathies. Tau-441 is known as "2N4R," "Isoform Tau-F," "Tau-4" or "Tau 441", which consisting of 441 amino acid. Tau-441 is a potential therapeutic target for pathogenesis.

Clinical and Translational Updates

Public Drug Information

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Flortaucipir F 18 18F-AV-1451; T807; F-18-AV-1451 Approved Siemens Medical Solution Tauvid United States Alzheimer Disease Avid Radiopharmaceuticals Inc 2020-05-28 Brain Injuries, Traumatic; Depression; Alzheimer Disease; Cognitive Dysfunction Details

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
BEY-2153 BEY-2153 Beyondbio Inc Details
ASN-120290 ASN-561; ASN-120290 Phase 1 Clinical Merck Serono Nerve Degeneration; Alzheimer Disease Details
ACI-3024 ACI-3024 Phase 1 Clinical Ac Immune Alzheimer Disease Details
Gosuranemab IPN-007; BIIB-092; huIPN-002; BMS-986168 Phase 2 Clinical Bristol-Myers Squibb Company, Ipierian Supranuclear Palsy, Progressive; Alzheimer Disease; Tauopathies Details
ISIS-814907 BIIB-080; ISIS-814907; IONIS-MAPTRx; ISIS-BIIB4Rx; IONIS-BIIB4RX Phase 2 Clinical Ionis Alzheimer Disease Details
Leuco methylthioninium LMTM; L-MTx; LMT-X; TRX-0237; Leuco-MTx Phase 3 Clinical Taurx Pharmaceuticals Alzheimer Disease; Dementia; Frontotemporal Dementia Details
[18F]GTP-1 [18F]GTP-1 Phase 2 Clinical Genentech Inc Alzheimer Disease; Diagnostic agents Details
MC-1 (Lilly) MC-1 (Lilly) Phase 1 Clinical Eli Lilly And Company Alzheimer Disease Details
[18F]THK-5105 [18F]THK-5105 Phase 2 Clinical Tohoku University Alzheimer Disease Details
RDC-5 RDC-5 Phase 1 Clinical Chronos Therapeutics Nerve Degeneration Details
18F-MNI-952 18F-UCB-K; 18F-MNI-952 Phase 1 Clinical Invicro Alzheimer Disease Details
[18F]THK-5117 [18F]THK-5117 Phase 2 Clinical Tohoku University Alzheimer Disease Details
BIIB-076 NI-105; BIIB-076 Phase 1 Clinical Biogen Inc, Neurimmune Alzheimer Disease Details
APN-1701 [18F]AM-PBB3; 18F-AM-PBB3; APN-1701 Phase 2 Clinical National Institute Of Radiological Sciences, Aprinoia Therapeutics Ltd Nerve Degeneration; Alzheimer Disease Details
Semorinemab RG-6100; MTAU-9937A; RO-7105705 Phase 2 Clinical Ac Immune Alzheimer Disease Details
R-phenserine ANVS-401; ANVS-405 Phase 2 Clinical Raptor Pharmaceutical Down Syndrome; Parkinson Disease; Cognitive Dysfunction; Alzheimer Disease Details
Lu-AF87908 Lu-AF87908 Phase 1 Clinical H. Lundbeck A/S Alzheimer Disease Details
FluoroTau [18F]THK-5351; GE-216; F-18-THK-5351 Phase 2 Clinical Tohoku University Nerve Degeneration; Alzheimer Disease Details
11C-PBB3 11C-PBB3 Clinical National Institute Of Radiological Sciences Alzheimer Disease Details
PI-2620 PI-2620; 18F-PI-2620 Phase 3 Clinical Piramal, Ac Immune Supranuclear Palsy, Progressive; Cognitive Dysfunction; Alzheimer Disease Details
APN-1607 [18F]PM-PBB3; APN-1607; 18F-PM-PBB3; 18F-APN-1607 Phase 2 Clinical Aprinoia Therapeutics Ltd Supranuclear Palsy, Progressive; Alzheimer Disease; Cognitive Dysfunction Details
Tilavonemab C2N-8E12; ABBV-8E12 Phase 2 Clinical C2n Diagnostics Supranuclear Palsy, Progressive; Alzheimer Disease Details
Mecripyrine Hydrochloride Y-1; SCR-1693 Phase 1 Clinical Jiangsu Xiansheng Pharmaceutical Co Ltd, Yantai Yene Pharma Co Ltd Alzheimer Disease Details
Alzheimer's disease vaccine (Axon Neuroscience) AADvac-1 Phase 1 Clinical Axon Biochemicals Alzheimer Disease; Primary Progressive Nonfluent Aphasia Details
[18F]MNI-958 APN-0000455; PM-PBB3 Molecular Neuroimaging Llc Details
ACI-35.030 ACI-35.030 Phase 2 Clinical Ac Immune Brain Diseases; Dementia; Alzheimer Disease; Tauopathies; Cognitive Dysfunction; Central Nervous System Diseases Details
ACI-35 ACI-35 Phase 1 Clinical Ac Immune Alzheimer Disease Details
Zagotenemab LY-3303560 Phase 2 Clinical Eli Lilly And Company Alzheimer Disease Details
PNT-001 PNT-001 Phase 1 Clinical Pinteon Therapeutics Brain Injuries, Traumatic; Alzheimer Disease Details
E-2814 E-2814 Phase 2 Clinical Eisai Co Ltd Alzheimer Disease Details
UCB-0107 UCB-0107 Phase 2 Clinical Ucb Supranuclear Palsy, Progressive; Alzheimer Disease Details

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