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IL-17C

IL-17C Protein Product ListCompare or Buy

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Cat. No. Species Product Description Structure Purity Feature
ILC-H52H7 Human Human IL-17C Protein, His Tag
ILC-H52H7-structure
ILC-H52H7-sds
ILC-H52H7-elisa_1
ILC-H82E5 Human Biotinylated Human IL-17C Protein, His,Avitag™
ILC-H82E5-structure
ILC-H82E5-sds
ILC-H82E5-elisa_1

IL-17C Part of Bioactivity data

ILC-H52H7-BLI
Human_FcRn_Heterodimer_Protein_Bli

Loaded Human IL-17 RE (155-454), Fc Tag (Cat. No. ILE-H5256) on Protein A Biosensor, can bind Human IL-17C, His Tag (Cat. No. ILC-H52H7) with an affinity constant of 0.714 nM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).

ILC-H82E5-ELISA
Biotinylated Human IL-17C, His,AvitagBiotinylated Human IL-17C, His,Avitag (Cat. No. ILC-H82E5) ELISA bioactivity

Immobilized Human IL-17 RE (155-454), Fc Tag (Cat. No. ILE-H5256) at 5 μg/mL (100 μL/well) can bind Biotinylated Human IL-17C, His,Avitag (Cat. No. ILC-H82E5) with a linear range of 0.5-13 ng/mL (QC tested).

IL-17C Molecule Synonym Name

IL-17C,Cytokine CX2,IL17C

IL-17C Molecule Background

Interleukin-17C(IL-17C) is a glycosylated cytokine that plays an important role in mucosal immunity and chronic inflammation. IL?17C binds to IL?17 RE with high affinity and to IL?17 RA with low affinity, binds to a heterodimer formed by IL17RA and IL17RE. Enhanced IL17C/IL17RE signaling may also lead to greater susceptibility to autoimmune diseases. Stimulates the production of antibacterial peptides and proinflammatory molecules for host defense by signaling through the NF-kappa-B and MAPK pathways. Acts synergically with IL22 in inducing the expression of antibacterial peptides, including S100A8, S100A9, REG3A and REG3G. Synergy is also observed with TNF and IL1B in inducing DEFB2 from keratinocytes.

IL-17C References

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