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Siglec-9

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Part of Bioactivity data

SI9-H5256-BLI
Human_FcRn_Heterodimer_Protein_Bli

Loaded Human Siglec-9, Fc Tag (Cat. No. SI9-H5256) on ProteinA Biosensor, can bind Neu5Ac(a2-6)GalNAc-PAA-biotin with an affinity constant of 0.85 μM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).

SI9-H5256-ELISA
Human Siglec-9, Fc TagHuman Siglec-9, Fc Tag (Cat. No. SI9-H5256) ELISA bioactivity

Immobilized Human Siglec-9, Fc Tag (Cat. No. SI9-H5256) at 10 μg/mL (100 μL/well) on Diamond Protein A Protein, His Tag precoated (0.5 μg/well) plate, can bind Neu5Ac(a2-6)GalNAc-PAA-biotin with a linear range of 0.156-2.5 μg/mL (QC tested).

Synonym Name

Siglec-9,SIGLEC9,CDw329,CD329

Background

siglec-9 (HGMW-approved symbol SIGLEC9) a member of the sialic acid-binding Ig-like lectin (Siglec) family, which belongs to the immunoglobulin superfamily (IgSF). SIGLEC9 shows a high degree of homology to many members of the siglec family, including siglec-7 (80%), siglec-8 (72%), siglec-5 (65%), and CD33 (64%). This high degree of homology is also conserved in the extracellular Ig-like domains. They are characterized by an N-terminal Ig-like V-type domain which mediates sialic acid binding, followed by varying numbers of Ig-like C2-type domains。Siglec-9 with a hydrophobic signal peptide, an N-terminal Ig-likeV-type domain, two Ig-like C2-type domains, a transmembrane region and a cytoplasmic tail.

Clinical and Translational Updates

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