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CD44

Brief Information

Name:CD44 antigen
Target Synonym:Hermes Antigen,Hyaluronate Receptor,Cell Surface Glycoprotein CD44,MC56,PGP-1,CD44,CDW44,GP90 Lymphocyte Homing/Adhesion Receptor,MIC4,LHR,Hematopoietic Cell E- And L-Selectin Ligand,CD44 Antigen (Homing Function And Indian Blood Group System),MDU3,Extrac
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:8
Lastest Research Phase:Phase 3 Clinical

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By Conjugate:
Cat. No. Species Product Description Structure Purity Feature
PG1-H5255 Human Human CD44 Protein, Fc Tag (HPLC-verified)
PG1-H5255-structure
PG1-H5255-sds
PG1-H5255-hplc
PG1-H5255-elisa_1
CD4-H5226 Human Human CD44 Protein, His Tag
CD4-H5226-structure
CD4-H5226-sds
CD4-H5226-elisa_1

Part of Bioactivity data

CD4-H5226-ELISA
Human CD44, His TagHuman CD44, His Tag (Cat. No. CD4-H5226) ELISA bioactivity

Immobilized Human CD44, His Tag (Cat. No. CD4-H5226) at 5 μg/mL (100 μL/well) can bind Hyaluronan biotin sodium salt with a linear range of 39-156 ng/mL (Routinely tested).

PG1-H5255-HPLC
Human CD44, Fc Tag (HPLC-verified) (Cat. No. ) HPLC images

The purity of Human CD44, Fc Tag (HPLC-verified) (Cat. No. PG1-H5255) was greater than 90% as determined by SEC-HPLC.

Synonym Name

CD44,CDW44,CSPG8,ECMR-III,HCELL,HUTCH-I,IN,LHR,MC56,MDU2,MDU3,MIC4,Pgp1,Epican

Background

CD44 antigen is a cell-surface glycoprotein involved in cell¨Ccell interactions, cell adhesion and migration. CD44 is expressed in a large number of mammalian cell types. CD44 is a receptor for hyaluronic acid and can also interact with other ligands, such as osteopontin, collagens, and matrix metalloproteinases (MMPs). CD44 function is controlled by its posttranslational modifications. One critical modification involves discrete sialofucosylations rendering the selectin-binding glycoform of CD44 called HCELL (for Hematopoietic Cell E-selectin/L-selectin Ligand). CD44 participates in a wide variety of cellular functions including lymphocyte activation, recirculation and homing, hematopoiesis, and tumor metastasis. Transcripts for this gene undergo complex alternative splicing that results in many functionally distinct isoforms.

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
CA-102N CA-102N Phase 1 Clinical Biobud Colorectal Neoplasms Details
Hyaluronic acid/Fluorouracil HA-5FU; HA-5-fluorouracil; Hyaluronic acid-5-fluorouracil complex; Hyaluronan acid-5-fluorouracil complex Phase 2 Clinical Monash University, Alchemia Colorectal Neoplasms Details
CD44v6-specific CAR gene-engineered T cell therapy (Shenzhen Geno-Immune Medical Institute) Phase 2 Clinical Shenzhen Geno-Immune Medical Institute Neoplasms Details
Multiple 4SCAR-T Cell Therapy (Shenzhen Geno-Immune Medical Institute) Phase 2 Clinical Shenzhen Geno-Immune Medical Institute Breast Neoplasms Details
AMC-303 AMC-303 Phase 1 Clinical Amcure Neoplasms Details
Clodronic acid/Hyaluronic acid Phase 1 Clinical Abiogen Pharma Spa Osteoarthritis Details
Hydrogen peroxide/Hyaluronic acid BMG-0703 Phase 3 Clinical University Of Milan Wounds and Injuries Details
MLM-CAR44.1 T-cell therapy (MolMed) Phase 2 Clinical Molmed Multiple Myeloma; Leukemia, Myeloid, Acute Details
Hyaluronic acid ETX-100; CTX-100 Phase 2 Clinical Actelion Pharmaceuticals Ltd alpha 1-Antitrypsin Deficiency; Asthma; Osteoarthritis, Knee Details

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