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CD44

CD44 Molecule Information

Name:CD44 antigen
Target Synonym:MDU2;CD44;Epican;Extracellular matrix receptor III;HUTCH-I;Hermes antigen;Phagocytic glycoprotein 1;MDU3;MIC4;Heparan sulfate proteoglycan;LHR ;CDw44;PGP-I;CD44 antigen;GP90 lymphocyte homing/adhesion receptor;CD_antigen=CD44;Hyaluronate receptor;Phagocyt
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:17
Lastest Research Phase:Phase ?

CD44 Protein Product ListCompare or Buy

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Cat. No. Species Product Description Structure Purity Feature
PG1-H5255 Human Human CD44 Protein, Fc Tag (HPLC-verified)
PG1-H5255-structure
PG1-H5255-sds
PG1-H5255-hplc
PG1-H5255-elisa_1
CD4-H5226 Human Human CD44 Protein, His Tag
CD4-H5226-structure
CD4-H5226-sds

CD44 Molecule Synonym Name

CD44,CDW44,CSPG8,ECMR-III,HCELL,HUTCH-I,IN,LHR,MC56,MDU2,MDU3,MIC4,Pgp1,Epican

CD44 Molecule Background

CD44 antigen is a cell-surface glycoprotein involved in cell¨Ccell interactions, cell adhesion and migration. CD44 is expressed in a large number of mammalian cell types. CD44 is a receptor for hyaluronic acid and can also interact with other ligands, such as osteopontin, collagens, and matrix metalloproteinases (MMPs). CD44 function is controlled by its posttranslational modifications. One critical modification involves discrete sialofucosylations rendering the selectin-binding glycoform of CD44 called HCELL (for Hematopoietic Cell E-selectin/L-selectin Ligand). CD44 participates in a wide variety of cellular functions including lymphocyte activation, recirculation and homing, hematopoiesis, and tumor metastasis. Transcripts for this gene undergo complex alternative splicing that results in many functionally distinct isoforms.

CD44 References

CD44 Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
VB1-050 (Sesen Bio) VBX-050; VB1-050,VBX 050; VB1 050,VBX050; VB1050 Preclinical Sesen Bio Colon cancer, Gastric cancer, Prostate cancer, Liver cancer Details
Hyaluronic acid/Fluorouracil Phase Ⅱ Monash University, Alchemia Metastatic colorectal cancer (CRC) Details
Hyaluronic acid (Actelion) CTX-100; ETX-100 Phase Ⅰ Actelion Alpha-1 antitrypsin deficiency, Asthma Details
RG-7356 RG-7356; RO-5429083 Phase Ⅰ Chugai, Roche Solid tumours, Acute myeloid Leukemia (AML) Details
VB-4011 (Sesen Bio) VB-4011 Preclinical Viventia Biotech, Sesen Bio Cancer Details
Bivatuzumab mertansine BIWI-1 Phase Ⅰ Boehringer Ingelheim, ImmunoGen Breast cancer, Head and neck cancer Details
VB1-008 (Sesen Bio) VB1-008; VBX-008,VB1 008; VBX 008,VB1008; VBX008 Preclinical Sesen Bio Cancer Details
NP-1 (Sesen Bio) NP-1 (Sesen Bio),NP 1 (Sesen Bio),NP1 (Sesen Bio) Preclinical Sesen Bio Cancer Details
Bivatuzumab BIWA-4; anti-CD44; anti-CD44 monoclonals Phase Ⅱ Boehringer Ingelheim Head and neck cancer Details
MLM-CAR44.1 T-cell therapy (MolMed) Phase Ⅱ MolMed Multiple myeloma (MM), Acute myeloid Leukemia (AML) Details
VB-6008 (Sesen Bio) VB-6008 Preclinical Viventia Biotech, Sesen Bio Cancer Details
CA-102N CA-102N Phase Ⅰ BioBud Colorectal cancer Details
SM-8849 SM-8849 Phase Ⅱ Sumitomo Dainippon Rheumatoid arthritis (RA) Details
AMC-303 AMC-303 Phase Ⅰ Amcure Solid tumours Details
VB-6050 (Sesen Bio) VB-6050 Preclinical Viventia Biotech, Sesen Bio Cancer Details
BV-5200 BV-5200; HYAL-BV5200 Phase Ⅱ SkyePharma Coronary restenosis Details
PF-3475952 PF-03475952; PF-3475952 Phase Ⅰ Pfizer Rheumatoid arthritis (RA) Details

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