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Your Position: Home > CD133

CD133

Brief Information

Name:CD133
Target Synonym:Antigen AC133,Prominin-1,PROM1,Prominin 1,Prominin-Like Protein 1,PROML1,Stargardt Disease 4 (Autosomal Dominant),Hematopoietic Stem Cell Antigen,Macular Dystrophy, Retinal 2,Prominin (Mouse)-Like 1,CD133 Antigen,HProminin,MSTP061,CORD12,AC133,CD133,MCDR2,STGD4,RP41,AC133 Antigen
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:0
Lastest Research Phase:Phase 2 Clinical

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Part of Bioactivity data

CD3-H82E6-Cell-based assay
FACS assay shows that recombinant Biotinylated FACS

2e5 of Anti-CD133 CAR-293 cells were stained with 100 μL of 3 μg/mL of Biotinylated Human CD133, His,Avitag (Nanodisc) (Cat. No. CD3-H82E6) and negative control protein respectively, washed and then followed by PE-SA and analyzed with FACS (QC tested).

CD3-H82Q8-SPR
Human_FcRn_Heterodimer_Protein_SPR

Monoclonal Anti-Human CD133 Antibody, Human IgG1 immobilized on CM5 Chip can bind Biotinylated Human CD133 Protein, His,Avitag (Cat. No. CD3-H82Q8) with an affinity constant of 22.9 nM as determined in a SPR assay (in presence of DDM and CHS) (Biacore 8K) (Routinely tested).

CD3-H82E6-SPR
Human_FcRn_Heterodimer_Protein_SPR

Monoclonal Anti-Human CD133 Antibody, Human IgG1 captured on CM5 chip via Anti-human IgG Fc antibodies surface can bind Biotinylated Human CD133, His,Avitag (Nanodisc) (Cat. No. CD3-H82E6) with an affinity constant of 61.2 nM as determined in a SPR assay (Biacore 8K) (Routinely tested).

Synonym Name

CD133,PROM1,PROML1,Prominin-1,AC133

Background

Prominin-1 is also known as CD133, Antigen AC133, PROM1, PROML1 and MSTP061. Is used as marker for hematopoietic stem and progenitor cells (HSPC) for somatic stem cell isolation. May play a role in cell differentiation, proliferation and apoptosis . Binds cholesterol in cholesterol-containing plasma membrane microdomains and may play a role in the organization of the apical plasma membrane in epithelial cells. During early retinal development acts as a key regulator of disk morphogenesis. Involved in regulation of MAPK and Akt signaling pathways. In neuroblastoma cells suppresses cell differentiation such as neurite outgrowth in a RET-dependent manner.

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
anti-CD133-CAR vector-transduced T cells Phase 2 Clinical The General Hospital Of The People'S Liberation Army Liver Neoplasms; Ovarian Neoplasms; Pancreatic Neoplasms; Breast Neoplasms; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Brain Neoplasms; Colorectal Neoplasms Details

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