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Your Position: Home > All Other Proteins > IL-1RL1 > Recombinant Human IL-1RL1 / ST2 / IL-33 R Protein

Human IL-1RL1 / ST2 Protein

  • Synonym
    IL1RL1,DER4,FIT-1,IL33R,ST2,ST2L,ST2V,T1
  • Source
    Human IL-1RL1, His Tag (IL1-H5229) is expressed from human 293 cells (HEK293). It contains AA Lys 19 - Phe 328 (Accession # Q01638-2).
    Predicted N-terminus: Lys 19
  • Molecular Characterization
    IL-1RL1(Lys 19 - Phe 328) Q01638-2

    This protein carries a polyhistidine tag at the C-terminus.

    The protein has a calculated MW of 36.9 kDa. The protein migrates as 48-60 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin
    Less than 1.0 EU per μg by the LAL method.
  • Purity

    >90% as determined by SDS-PAGE.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    No activity loss is observed after storage at:

    1. 4-8°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
SDS-PAGE
Human IL-1RL1, His Tag (Cat. No. IL1-H5229) SDS-PAGE gel

Human IL-1RL1, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 90%.

Bioactivity
Human IL-1RL1, His TagHuman IL-1RL1, His Tag (Cat. No. IL1-H5229) ELISA bioactivity

Immobilized Human IL33 at 5 μg/mL (100 μL/well) can bind Human IL-1RL1, His Tag (Cat. No. IL1-H5229) with a linear range of 63-500 ng/mL (Routinely tested).

  • Background
    Interleukin 1 receptor-like 1 (IL1RL1) is also known as ST2, DER4, FIT-1, IL33R, ST2L, ST2V, which belongs to the interleukin-1 receptor family. IL1RL1 contains three Ig-like C2-type (immunoglobulin-like) domains and one TIR domain. IL1RL1 is receptor for interleukin-33 (IL-33), its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8. IL1RL1 possibly involved in helper T-cell function. IL1RL1 can interact with MYD88, IRAK1, IRAK4, and TRAF6.
  • References
  • Please contact us via TechSupport@acrobiosystems.com if you have any question on this product.

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