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Your Position: Home > Bio-Markers & CD Antigens > IL-1RL1 > Human IL1RL1 /ST2 Protein, With C-Fc Tag

Human IL-1RL1 / ST2 Protein, Fc Tag

  • Synonym
  • Source
    Human IL-1RL1, Fc Tag (IL1-H5250) is expressed from human 293 cells (HEK293). It contains AA Lys 19 - Pro 323 (Accession # NP_003847).
    Predicted N-terminus: Lys 19
  • Molecular Characterization
    IL-1RL1(Lys 19 - Pro 323) NP_003847

    This protein carries a human IgG1 Fc tag at the C-terminus.

    The protein has a calculated MW of 61 kDa. The protein migrates as 85-100 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin
    Less than 1.0 EU per μg by the LAL method.
  • Purity

    >90% as determined by SDS-PAGE.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in 50 mM Tris, 100 mM Glycine, pH7.5. Normally trehalose is added as protectant before lyophilization.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    No activity loss is observed after storage at:

    1. 4-8°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
Human IL-1RL1, Fc Tag (Cat. No. IL1-H5250) SDS-PAGE gel

Human IL-1RL1, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 90%.

Human IL-1RL1, Fc TagHuman IL-1RL1, Fc Tag (Cat. No. IL1-H5250) ELISA bioactivity

Immobilized Human IL-33, Tag Free (Cat. No. IL3-H4112) at 5μg/mL (100 μL/well) can bind Human IL-1RL1, Fc Tag (Cat. No. IL1-H5250) with a linear range of 1.95-7.8 ng/mL (QC tested).

  • Background
    Interleukin 1 receptor-like 1 (IL1RL1) is also known as ST2, DER4, FIT-1, IL33R, ST2L, ST2V, which belongs to the interleukin-1 receptor family. IL1RL1 contains three Ig-like C2-type (immunoglobulin-like) domains and one TIR domain. IL1RL1 is receptor for interleukin-33 (IL-33), its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8. IL1RL1 possibly involved in helper T-cell function. IL1RL1 can interact with MYD88, IRAK1, IRAK4, and TRAF6.
  • References
  • Please contact us via TechSupport@acrobiosystems.com if you have any question on this product.

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