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Your Position: Home > Other Recombinant Proteins > MAD2L1 > Human MAD2L1 /MAD2 Protein

Human MAD2L1 Protein

  • Synonym
    MAD2L1,MAD2,HsMAD2
  • Source
    Human MAD2L1, His Tag (MA1-H5123) is expressed from E.coli cells. It contains AA Met 1 - Asp 205 (Accession # NP_002349).
    Predicted N-terminus: Met 1
  • Molecular Characterization
    MAD2L1(Met 1 -  Asp 205) NP_002349

    This protein carries a polyhistidine tag at the C-terminus.

    The protein has a calculated MW of 24.3 kDa. The protein migrates as 24 kDa under reducing (R) condition (SDS-PAGE).

  • Endotoxin
    Less than 1.0 EU per μg by the LAL method.
  • Purity

    >95% as determined by SDS-PAGE.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    No activity loss is observed after storage at:

    1. 4-8°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
SDS-PAGE
Human MAD2L1, His Tag (Cat. No. MA1-H5123) SDS-PAGE gel

Human MAD2L1, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.

  • Background
    Mitotic arrest deficient 2-like protein 1 (MAD2L1) is also known as Mitotic spindle assembly checkpoint protein MAD2A (HsMAD2), MAD2. MAD2L1 / MAD2 belongs to the MAD2 family. MAD2L1 / MAD2 contains one HORMA domain. MAD2L1 is the component of the spindle-assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. MAD2L1 / MAD2 is required for the execution of the mitotic checkpoint which monitors the process of kinetochore-spindle attachment and inhibits the activity of the anaphase promoting complex by sequestering CDC20 until all chromosomes are aligned at the metaphase plate.
  • References
  • Please contact us via TechSupport@acrobiosystems.com if you have any question on this product.

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