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Your Position: Home > Cytokines & Growth Factors > Human ANGPTL3 / ANGPT5 Protein

Human Angiopoietin-like 3 / ANGPTL3 Protein

  • Synonym
    ANGPTL3,ANGPT5,ANG-5,Angiopoietin-5,FHBL2
  • Source
    Human Angiopoietin-like 3, His Tag (AN3-H5226) is expressed from human 293 cells (HEK293). It contains AA Ser 17 - Pro 220 (Accession # NP_055310).
    Predicted N-terminus: Ser 17
  • Molecular Characterization
    ANGPTL3(Ser 17 - Pro 220) NP_055310

    This protein carries a polyhistidine tag at the C-terminus.

    The protein has a calculated MW of 24.6 kDa. The protein migrates as 26-38 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin
    Less than 1.0 EU per μg by the LAL method.
  • Purity

    >95% as determined by reduced SDS-PAGE.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    No activity loss is observed after storage at:

    1. 4-8°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
SDS-PAGE
Human Angiopoietin-like 3, His Tag (Cat. No. AN3-H5226) SDS-PAGE gel

Human Angiopoietin-like 3, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.

  • Background
    Angiopoietin-like protein 3 (ANGPTL3) is also known as Angiopoietin-related protein 3, Angiopoietin-5 (ANGPT5 / ANG-5), is a member of the angiopoietin-like family of secreted factors. ANGPTL3 / ANGPT5 is predominantly expressed in the liver, and has the characteristic structure of angiopoietins, consisting of a signal peptide, N-terminal coiled-coil domain and the C-terminal fibrinogen (FBN)-like domain. The FBN-like domain in angiopoietin-like 3 protein was shown to bind alpha-5/beta-3 integrins, and this binding induced endothelial cell adhesion and migration. This protein may also play a role in the regulation of angiogenesis. Angptl3 also acts as dual inhibitor of lipoprotein lipase (LPL) and endothelial lipase (EL), and increases plasma triglyceride and HDL cholesterol in rodents. ANGPTL3 inhibit endothelial lipase to catalyze HDL-phospholipid and increase HDL-PL levels. Circulating PL-riched HDL particles have high cholesterol efflux abilities.
  • References
  • Please contact us via TechSupport@acrobiosystems.com if you have any question on this product.

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