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Your Position: Home > All Other Proteins > Lumican > Human Lumican /LUM Protein

Human Lumican Protein

  • Synonym
    LUM,Lumican,LDC,SLRR2D,KSPG lumican
  • Source
    Human Lumican, His Tag (LUM-H5227) is expressed from human 293 cells (HEK293). It contains AA Gln 19 - Asn 338 (Accession # NP_002336).
    Predicted N-terminus: Gln 19
  • Molecular Characterization
    Lumican(Gln 19 - Asn 338) NP_002336

    This protein carries a polyhistidine tag at the C-terminus.

    The protein has a calculated MW of 37.5 kDa. The protein migrates as 50-65 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin
    Less than 1.0 EU per μg by the LAL method.
  • Purity

    >95% as determined by reduced SDS-PAGE.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    No activity loss is observed after storage at:

    1. 4-8°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
SDS-PAGE
Human Lumican, His Tag (Cat. No. LUM-H5227) SDS-PAGE gel

Human Lumican, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.

  • Background
    Lumican (LUM) is also known as Keratan sulfate proteoglycan lumican, KSPG lumican,LDC and SLRR2D, which belongs to the small leucine-rich proteoglycan (SLRP) family and SLRP class II subfamily. LUM /Lumican is present in the extracellular matrix of human articular cartilage at all ages, although its abundance is far greater in the adult. In the adult cartilage LUM /Lumican exists predominantly in a glycoprotein form lacking keratan sulfate, whereas the juvenile form of the molecule is a proteoglycan. LUM participates in the maintenance of tissue homeostasis and modulates cellular functions including cell proliferation, migration, and differentiation. The expression of LUM has been correlated to the growth and metastasis of various malignancies.
  • References
  • Please contact us via TechSupport@acrobiosystems.com if you have any question on this product.

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