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Your Position: Home > All Other Proteins > IFN-alpha/beta R2 > Human IFNAR2 /IFNABR Protein,C-Fc Tag

Human IFN-alpha / beta R2 Protein, Fc Tag

  • Synonym
    IFNAR2,IFNARB,IFNABR,IFN-R-2,IFN-alpha/beta receptor 2
  • Source
    Human IFN-alpha/beta R2, Fc Tag (IF2-H5255) is expressed from human 293 cells (HEK293). It contains AA Ile 27 - Lys 243 (Accession # NP_997467).
    Predicted N-terminus: Ile 27
  • Molecular Characterization
    IFNAR2(Ile 27 - Lys 243) NP_997467

    This protein carries a human IgG1 Fc tag at the C-terminus.

    The protein has a calculated MW of 51.4 kDa. The protein migrates as 66-90 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin
    Less than 1.0 EU per μg by the LAL method.
  • Purity

    >95% as determined by SDS-PAGE.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in 50 mM Tris, 100 mM Glycine, pH7.5. Normally trehalose is added as protectant before lyophilization.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    No activity loss is observed after storage at:

    1. 4-8°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
SDS-PAGE
Human IFN-alpha/beta R2, Fc Tag (Cat. No. IF2-H5255) SDS-PAGE gel

Human IFN-alpha/beta R2, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.

  • Background
    Interferon alpha/beta receptor 2 (IFNAR2) is also known as IFN-alpha binding protein, IFN-alpha/beta receptor 2, Type I interferon receptor 2, IFNABR and IFNARB, which is a single-pass type I membrane protein and belongs to the type II cytokine receptor family. IFNAR2 can associate with IFNAR1 to form the type I interferon receptor. IFNAR2 is a receptor for interferons alpha and beta.IFNAR2 involves in IFN-mediated STAT1, STAT2 and STAT3 activation. Isoform 1 and isoform 2 of IFNAR2 are directly involved in signal transduction due to their association with the TYR kinase, JAK1. Isoform 3 of IFNAR2 is a potent inhibitor of type I IFN receptor activity.Genetic variations in IFNAR2 influence susceptibility to hepatitis B virus (HBV) infection.
  • References
  • Please contact us via TechSupport@acrobiosystems.com if you have any question on this product.

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Price(USD) : $1600.00

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