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Your Position: Home > All Other Proteins > IL-17 RA > Human IL17RA /CD217 Protein,C-Fc Tag

Human IL-17 RA / CD217 Protein, Fc Tag

  • Synonym
    CD217,CDw217,IL-17RA,IL17R,CANDF5,hIL-17R
  • Source
    Human IL-17 RA, Fc Tag (ILA-H5257) is expressed from human 293 cells (HEK293). It contains AA Leu 33 - Trp 320 (Accession # NP_055154.3).
    Predicted N-terminus: Leu 33
  • Molecular Characterization
    IL-17 RA(Leu 33 - Trp 320) NP_055154.3

    This protein carries a human IgG1 Fc tag at the C-terminus.

    The protein has a calculated MW of 60.1 kDa. The protein migrates as 71-90 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin
    Less than 1.0 EU per μg by the LAL method.
  • Purity

    >95% as determined by SDS-PAGE.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in 50 mM Tris, 100 mM Glycine, 10 mM NaCl, pH7.5. Normally trehalose is added as protectant before lyophilization.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    No activity loss is observed after storage at:

    1. 4-8°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
SDS-PAGE
Human IL-17 RA, Fc Tag (Cat. No. ILA-H5257) SDS-PAGE gel

Human IL-17 RA, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.

Bioactivity
Human IL-17 RA, Fc TagHuman IL-17 RA, Fc Tag (Cat. No. ILA-H5257) ELISA bioactivity

Immobilized Human IL17 /IL17A,Tag Free (Cat. No. ILA-H5118) at 2 μg/mL (100 μL/well ) can bind Human IL-17 RA, Fc Tag (Cat. No. ILA-H5257) with a linear ranger of 0.3-5 ng/mL (QC tested).

  • Background
    Interleukin 17 receptor A (IL17RA) is also known as cluster of differentiation w217 (CDw217), is a pro-inflammatory cytokine secreted by activated T-lymphocytes, belong to ubiquitous type I membrane glycoprotein, and binds with low affinity to interleukin 17A (IL17A). IL 17R mRNA exhibits a broad tissue distribution, and has been detected in virtually all cells and tissues tested . IL 17RA associates with IL 17RC to form a signaling receptor complex for IL 17 and IL 17F . Ligand and IL 17RA ligation promotes T cell activation and the production of IL - 6, G-CSF, SCF, and multiple pro-inflammatory chemokines. Defects in IL17RA are the cause of familial candidiasis type 5 (CANDF5).
  • References
  • Please contact us via TechSupport@acrobiosystems.com if you have any question on this product.

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