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Your Position: Home > Cytokines > BMP-2 > Human-BMP-2-Protein

Human BMP-2 Protein, Tag Free

  • Synonym
    BMP2,BMP2A
  • Source
    Human BMP-2, Tag Free (BM2-H4117) is expressed from E.coli cells. It contains AA Ala 284 - Arg 396 (Accession # NP_001191).
    Predicted N-terminus: Met
  • Molecular Characterization
    Online(Ala 284 - Arg 396) NP_001191

    This protein carries no "tag".

    The protein has a calculated MW of 13.0 kDa. the protein migrates as 14 kDa under reducing (R) condition, and 28 kDa under non-reducing (NR) condition (SDS-PAGE).

  • Endotoxin
    Less than 1.0 EU per μg by the LAL method.
  • Purity

    >92% as determined by SDS-PAGE.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in 100 mM Acetic Acid, pH2.0. Normally trehalose is added as protectant before lyophilization.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    No activity loss was observed after storage at:

    1. 4-8°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
SDS-PAGE
Human BMP-2, Tag Free (Cat. No. BM2-H4117) SDS-PAGE gel

Human BMP-2, Tag Free on SDS-PAGE under reducing (R) and non-reducing (NR) conditions. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 92%.

Bioactivity-ELISA
Human BMP-2, Tag FreeHuman BMP-2, Tag Free (Cat. No. BM2-H4117) ELISA bioactivity

Immobilized Human BMP-2, Tag Free (Cat. No. BM2-H4117) at 2 μg/mL (100 μL/well) can bind Human Gremlin, Fc Tag (Cat. No. GR1-H5254) with a linear range of 5-78 ng/mL (QC tested).

  • Background
    Human bone morphogenetic protein 2 (BMP2) is also known as human BMP-2, BMP-2, BMP2, BMP 2, h-BMP-2, rh-BMP-2, recombinant human BMP-2, recombinant BMP-2, BMP, is a member of the BMP subgroup belonging to the TGF-b superfamily of structurally related signaling proteins. BMP-2 is a potent osteoinductive cytokine, capable of inducing bone and cartilage formation in association with osteoconductive carriers such as collagen and synthetic hydroxyapatite. In addition to its osteogenic activity, BMP-2 plays an important role in cardiac morphogenesis and is expressed in a variety of tissues including lung, spleen, brain, liver, prostate ovary and small intestine. As implied by its name, BMPs promote and regulate bone development, growth, remodeling and repair, in both prenatal development and postnatal growth of eye, heart, kidney, skin, and other tissues. BMP2 has been demonstrated to potently induce osteoblast differentiation in a variety of cell types, and induce apoptosis in human myeloma cell lines as a novel function.
  • References
  • Please contact us via TechSupport@acrobiosystems.com if you have any question on this product.

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