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Your Position: Home > All Other Proteins > LILRA3 > Human LILRA3 /ILT6 Protein,C-Fc Tag

Human LILRA3 / CD85e Protein, Fc Tag

  • Synonym
    LILRA3,ILT6,LIR4,CD85e
  • Source
    Human LILRA3, Fc Tag (LI3-H5256) is expressed from human 293 cells (HEK293). It contains AA Gly 24 - Glu 439 (Accession # AAH28208).
    Predicted N-terminus: Gly 24
  • Molecular Characterization
    Online(Gly 24 - Glu 439) AAH28208

    This protein carries a human IgG1 Fc tag at the C-terminus.

    The protein has a calculated MW of 71.7 kDa. The protein migrates as 102 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin
    Less than 1.0 EU per μg by the LAL method.
  • Purity

    >92% as determined by SDS-PAGE.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in 50 mM Tris, 100 mM Glycine, pH7.5. Normally trehalose is added as protectant before lyophilization.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    No activity loss was observed after storage at:

    1. 4-8°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
SDS-PAGE
Human LILRA3, Fc Tag (Cat. No. LI3-H5256) SDS-PAGE gel

Human LILRA3, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 92%.

  • Background
    Leukocyte immunoglobulin-like receptor subfamily A member 3 (LILRA3) is also known as CD85 antigen-like family member E (CD85e), immunoglobulin-like transcript 6 (ILT-6), and leukocyte immunoglobulin-like receptor 4 (LIR-4) is a protein that in humans is encoded by the LILRA3 gene located within the eukocyte receptor complex on chromosome 19q13.4. Unlike many of its family, LILRA3 lacks a transmembrane domain, which contains 4 Ig-like C2-type (immunoglobulin-like) domains. LILRA3 acts as soluble receptor for class I MHC antigens. At the same time,LILRA3 can bind both classical and non-classical HLA class I molecules but with reduced affinities compared to LILRB1 or LILRB2. Also,LILRA3 can bind with high affinity to the surface of monocytes, leading to abolish LPS-induced TNF-alpha production by monocytes.
  • References
  • Please contact us via TechSupport@acrobiosystems.com if you have any question on this product.

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