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Your Position: Home > Immune Checkpoint Proteins > HVEM > Human HVEM / TNFRSF14 Protein

Human HVEM / TNFRSF14 Protein

  • Synonym
  • Source
    Human HVEM, His Tag (HVM-H52E9) is expressed from human 293 cells (HEK293). It contains AA Leu 39 - Val 202 (Accession # NP_003811).
    Predicted N-terminus: Leu 39
  • Molecular Characterization
    HVEM(Leu 39 - Val 202) NP_003811

    This protein carries a polyhistidine tag at the C-terminus.

    The protein has a calculated MW of 19.2 kDa. The protein migrates as 33-40 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin
    Less than 1.0 EU per μg by the LAL method.
  • Purity

    >90% as determined by SDS-PAGE.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    No activity loss is observed after storage at:

    1. 4-8°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
Human HVEM, His Tag (Cat. No. HVM-H52E9) SDS-PAGE gel

Human HVEM, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 90%.

Human HVEM, His TagHuman HVEM, His Tag (Cat. No. HVM-H52E9) ELISA bioactivity

Immobilized Human HVEM, His Tag (Cat. No. HVM-H52E9) at 0.5 μg/mL (100 μL/well) can bind Human BTLA, Fc Tag (Cat. No. BTA-H5255) with a linear range of 0.078-2.5 μg/mL (QC tested).

Human HVEM, His TagHuman HVEM, His Tag (Cat. No. HVM-H52E9) ELISA bioactivity

Immobilized Human HVEM, His Tag (Cat.No. HVM-H52E9) at 5 μg/mL (100 μL/well) can bind Human BTLA (31-150), Fc Tag (Cat.No. BTA-H5256) with a linear range of 0.08-1.25 μg/mL (Routinely tested).

  • Background
    Herpesvirus entry mediator (HVEM) is also known as TNFRSF14, TR2 (TNF receptorlike molecule) and ATAR (another TRAF associated receptor), is a type I membrane protein belonging to the TNF/NGF receptor superfamily. HVEM expression has been detected in peripheral blood T cells, B cells, monocytes and in various tissues enriched in lymphoid cells. The extracellular domain of HVEM has been shown to interact directly with the herpes simplex virus envelope glycoprotein D (gD). Two TNF superfamily ligands, including the secreted TNFβ (lymphotoxin α) and the membrane protein LIGHT (lymphotoxins, exhibits inducible expression, and competes with HSV glycoprotein D for HVEM, a receptor expressed by T lymphocytes), have been shown to be the cellular ligands for HVEM. Besides HVEM, LIGHT can also interact with LTβR, the receptor for lymphotoxin αβ heterotrimer. The role of the HVEM LIGHT /LTβ receptor ligand pair in immune function and herpesvirus pathobiology remains to be elucidated.
  • References
  • Please contact us via TechSupport@acrobiosystems.com if you have any question on this product.

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