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Your Position: Home > All Other Proteins > BCMA > Cynomolgus / Rhesus macaque BCMA / TNFRSF17 Protein

Cynomolgus / Rhesus macaque BCMA / TNFRSF17 Protein

INTRODUCTION

QC & Assay Protocol

Citation & Background

Synonym
TNFRSF17,CD269,BCM,BCMA
Source
Cynomolgus / Rhesus macaque BCMA (BCA-C52H7) is expressed from human 293 cells (HEK293). It contains AA Met 1 - Ala 53 (Accession # G7Q0I4-1).
Predicted N-terminus: Met 1
Request for sequence
Molecular Characterization
This protein carries a polyhistidine tag at the C-terminus.
The protein has a calculated MW of 7.9 kDa. The protein migrates as 16-20 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin
Less than 1.0 EU per μg by the LAL method.
Purity
>90% as determined by SDS-PAGE.

Formulation
Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization.
Contact us for customized product form or formulation.
Reconstitution
Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Storage
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
No activity loss was observed after storage at:
1. 4-8^°C for 12 months in lyophilized state;
2. -70^°C for 3 months under sterile conditions after reconstitution.

SDS-PAGE

Cynomolgus / Rhesus macaque BCMA on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 90%.

Bioactivity-ELISA

Cynomolgus / Rhesus macaque BCMACynomolgus / Rhesus macaque BCMA (Cat. No. BCA-C52H7) ELISA bioactivity

Immobilized Human BAFF, Fc Tag (Cat. No. BAF-H4268) at 5 μg/mL (100 μL/well) can bind Cynomolgus / Rhesus macaque BCMA (Cat. No. BCA-C52H7) with a linear range of 0.078-0.625 μg/mL (QC tested).

Request for protocol

Background
Tumor necrosis factor receptor superfamily member 17 (TNFRSF17) is also known as B-cell maturation protein (BCMA), CD antigen CD269, which is a member of the TNF-receptor superfamily. TNFRSF17 contains one TNFR-Cys repeat. TNFRSF17 is expressed in mature B-cells, but not in T-cells or monocytes. TNFRSF17 is receptor for TNFSF13B/BLyS/BAFF and TNFSF13/APRIL. TNFRSF17 promotes B-cell survival and plays a role in the regulation of humoral immunity. TNFRSF17 can activate NF-kappa-B and JNK.
References
Please contact us via TechSupport@acrobiosystems.com if you have any question on this product.