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Your Position: Home > Recombinant Proteins > TROP-2 > Human TROP-2 / TACSTD2 Protein

Human TROP-2 / TACSTD2 Protein

  • Synonym
    TACSTD2,GA733-1,M1S1,TROP2
  • Source
    Human TROP-2 (TR2-H5223) is expressed from human 293 cells (HEK293). It contains AA His 27 - Thr 274 (Accession # P09758-1).
    Predicted N-terminus: His 27
  • Molecular Characterization
    TROP-2(His 27 - Thr 274) P09758-1

    This protein carries a polyhistidine tag at the C-terminus.

    The protein has a calculated MW of 29.8 kDa. The protein migrates as 40-50 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin
    Less than 1.0 EU per μg by the LAL method.
  • Purity

    >95% as determined by SDS-PAGE.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    No activity loss is observed after storage at:

    1. 4-8°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
SDS-PAGE
Human TROP-2 (Cat. No. TR2-H5223) SDS-PAGE gel

Human TROP-2 on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.

  • Background
    TROP-2 is a single-copy gene in human cells, and encodes a type-1 transmembrane glycoprotein which is over-expressed in various malignancies, also referred to as tumor associated calcium signal transducer 2 (TACSTD2), GA733-1 or M1S1. TROP-2 is related to epithelial cell adhesion molecule (EpCAM), also called TROP-1, gp40, and KSA. Trop-1 and Trop-2 are homologous to serum IGF-II-binding proteins and appear as signal transducers. Thus, they likely represent novel cell-surface receptors and may play a role in regulating the growth of carcinoma cells.
  • References
  • Please contact us via TechSupport@acrobiosystems.com if you have any question on this product.

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