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Your Position: Home > Recombinant Proteins > Integrin alpha 4 beta 7 > Human Integrin alpha 4 beta 7 (ITGA4&ITGB7) Heterodimer Protein

Human Integrin alpha 4 beta 7 (ITGA4&ITGB7) Heterodimer Protein

  • Synonym
    Integrin alpha 4 beta 7,ITGA4&ITGB7
  • Source
    Recombinant Human ITGA4 & ITGB7 Heterodimer Protein (IT7-H52W4) is expressed from human 293 cells (HEK293). It contains AA Tyr 34 - Thr 977 (ITGA4) & Glu 20 - His 723 (ITGB7) (Accession # P13612-1 (ITGA4) & P26010-1 (ITGB7)).
    Predicted N-terminus: Tyr 34 (ITGA4) & Glu 20 (ITGB7)
  • Molecular Characterization
    ITGA4&ITGB7(Tyr 34 - Thr 977 (ITGA4) & Glu 20 - His 723 (ITGB7)) P13612-1 (ITGA4) & P26010-1 (ITGB7)

    Human ITGA4 & ITGB7 Heterodimer Protein, produced by co-expression of ITGA4 and ITGB7, has a calculated MW of 111.4 kDa (ITGA4) & 81.8 kDa (ITGB7). Subunit ITGA4 is fused with an acidic tail at the C-terminus and followed by a polyhistidine tag and subunit ITGB7 contains no tag but a basic tail at the C-terminus. The predicted N-terminus is Tyr 34 (ITGA4) & Glu 20 (ITGB7). The reducing (R) protein migrates as 60-80 kDa (ITGA4) and 105-115 kDa and 130 kDa (ITGB7) respectively due to glycosylation.

  • Endotoxin
    Less than 1.0 EU per μg by the LAL method.
  • Purity

    >90% as determined by SDS-PAGE.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in 50 mM Tris, 100 mM NaCl, pH8.0. Normally trehalose is added as protectant before lyophilization.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    No activity loss is observed after storage at:

    1. 4-8°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
Human ITGA4 & ITGB7 (Cat. No. IT7-H52W4) SDS-PAGE gel

Human ITGA4 & ITGB7 on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 90%.

Human ITGA4 & ITGB7Human ITGA4 & ITGB7 (Cat. No. IT7-H52W4) ELISA bioactivity

Immobilized Natalizumab at 1 μg/mL (100 μL/well) can bind Human ITGA4 & ITGB7 (Cat. No. IT7-H52W4) with a linear range of 8-125 ng/mL (QC tested).

  • Background
    Integrin alpha 4 beta 7 is an integrin family adhesion receptor that shares subunits with alpha 4 beta 1 (VLA4) and the E-Cadherin receptor, alpha E beta 7 . Integrin alpha 4 beta 7, which is critical for homing to intestinal mucosa, is induced during T cell activation in Peyer’s patches or mesenteric lymph nodes.Its expression requires signals from local dendritic and stromal cells, including secreted retinoic acid. The HIV-1 envelope protein gp120 binds to the active form of Integrin alpha 4 beta 7, and this may or may not account for the concentration of HIV-1 virus in the gut-associated lymphoid tissue (GALT). Integrin alpha 4 beta 7 may also be involved in lymphocyte trafficking in acute intestinal graft vs. host disease (GVHD).
  • References
  • Please contact us via TechSupport@acrobiosystems.com if you have any question on this product.

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Price(USD) : $410.00

Price(USD) : $2880.00

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