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Your Position: Home > All Other Proteins > Siglec-2 > Rhesus macaque Siglec-2 / CD22 Protein

Rhesus macaque Siglec-2 / CD22 Protein

  • Synonym
    CD22,SIGLEC2,BL-CAM,Leu-14
  • Source
    Rhesus macaque Siglec-2 (SI2-R52Ha) is expressed from human 293 cells (HEK293). It contains AA Ser 20 - Arg 686 (Accession # EHH29920.1).
    Predicted N-terminus: Ser 20
  • Molecular Characterization
    Siglec-2(Ser 20 - Arg 686) EHH29920.1

    This protein carries a polyhistidine tag at the C-terminus.

    The protein has a calculated MW of 76.9 kDa. The protein migrates as 95-120 KDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin
    Less than 1.0 EU per μg by the LAL method.
  • Purity

    >95% as determined by SDS-PAGE.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    No activity loss is observed after storage at:

    1. 4-8°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
SDS-PAGE
Rhesus macaque Siglec-2 (Cat. No. SI2-R52Ha) SDS-PAGE gel

Rhesus macaque Siglec-2 on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.

  • Background
    B-cell receptor CD22 is also known as Sialic acid-binding Ig-like lectin 2 (Siglec-2), B-lymphocyte cell adhesion molecule (BL-CAM), T-cell surface antigen Leu-14, which belongs to the immunoglobulin superfamily and SIGLEC (sialic acid binding Ig-like lectin) family. CD22 mediates B-cell B-cell interactions, and may be involved in the localization of B-cells in lymphoid tissues. Siglec-2 / CD22 binds sialylated glycoproteins, one of which is CD45. Siglec2 / CD22 plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules.
  • References
  • Please contact us via TechSupport@acrobiosystems.com if you have any question on this product.

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