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Your Position: Home > All Other Proteins > MIS > Human MIS / AMH Protein, His Tag

Human MIS / AMH Protein, His Tag

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  • Synonym
    MIS,AMH,MIF
  • Source
    Human MIS, His Tag (MIS-H52H5) is expressed from human 293 cells (HEK293). It contains AA Arg 26 - Arg 560 (Accession # P03971-1).
    Predicted N-terminus: His
  • Molecular Characterization
    Online-Res(Arg 26 - Arg 560) P03971-1

    This protein carries a polyhistidine tag at the N-terminus.

    The protein has a calculated MW of 58.6 kDa.

  • Endotoxin
  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    No activity loss was observed after storage at:

    1. 4-8°C for 12 months in lyophilized state;

    2. -70°C for 3 months under sterile conditions after reconstitution.

  • Background
    AMH is a dimeric glycoprotein with a molar mass of 140 kDa. The molecule consists of two identical subunits linked by sulfide bridges, and characterized by the N-terminal dimer (pro-region) and C-terminal dimer. This glycoprotein, produced by the Sertoli cells of the testis, causes regression of the Muellerian duct. It is also able to inhibit the growth of tumors derived from tissues of Muellerian duct origin. The best-known and most specific effect, mediated through the AMH type II receptors, includes programmed cell death (apoptosis) of the target tissue (the fetal Müllerian ducts).  AMH binds to its Type 2 receptor AMHR2, which phosphorylizes a type I receptor under the TGF beta signaling pathwa. AMH works by interacting with specific receptors on the surfaces of the cells of target tissues (anti-Müllerian hormone receptors).
  • References
  • Please contact us via TechSupport@acrobiosystems.com if you have any question on this product.

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