This product is still under development. Please contact us if you have interest in this product. We will accelerate the development process accordingly and reserve this product for you as request.
Biotinylated Human ErbB3, His,Avitag (ER3-H82E6) is expressed from human 293 cells (HEK293). It contains AA Ser 20 - Thr 643 (Accession # P21860-1).
Predicted N-terminus: Ser 20
This protein carries a polyhistidine tag at the C-terminus, followed by an Avi tag.
The protein has a calculated MW of 72.4 kDa.
Biotinylation of this product is performed using Avitag™ technology. Briefly, the single lysine residue in the Avitag is enzymatically labeled with biotin.
ErbB3,also known as Her3 (human epidermal growth factor receptor 3), is a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound glycoprotein has a neuregulin binding domain but has not an active kinase domain. It therefore can bind the ligand but cannot mediate the intracellular signal transduction through protein phosphorylation. However, it does form heterodimers with ErbB2 or other EGFR members responsible for tyrosine phosphorylation to give a receptor complex and initiate the related pathway, which lead to cell proliferation or differentiation. Overexpression of this protein has been reported in numerous cancers, including prostate, bladder, and breast tumors. This protein has different isoforms derived from alternative splicing variants, and among which, the secreted isoform lacking the intermembrane region modulates the activity of membrane-bound form.
- (1) Singer, E. etal., 2001, J. Biol. Chem. 276 (47): 44266–74.
- (2) Kraus,M.H.etal.,1989,Proc.Natl.Acad.Sci.86:9193-9197.
- (3) Carraway,K.L.et al., 1994, J.Biol.Chem., 269: 14303-14306.
- (4) Wallasch,C.et al.,1995,EMBO.J.14:4267-4275.
- (5) Alimandi,M.et al.,1995,Oncogene.10:1813-1821.
- (6) Gamett,D.C.et al.,1995,J.Biol.Chem.270:19022-19027.