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Your Position: Home > Viral Proteins > S2 protein > S2N-C52H3

2019-nCoV S2 protein, His Tag

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  • Synonym
    S2 protein,Spike glycoprotein Subunit2,S glycoprotein Subunit2,Spike protein S2
  • Source
    2019-nCoV S2 protein, His Tag (S2N-C52H3) is expressed from human 293 cells (HEK293). It contains AA Ser 686 - Thr 1273 (Accession # QHD43416.1).
    Predicted N-terminus: Ser 686
  • Molecular Characterization
    Online-Res(Ser 686 - Thr 1273) QHD43416.1

    This protein carries a polyhistidine tag at the C-terminus.

    The protein has a calculated MW of 66.4 kDa.

  • Endotoxin
  • Formulation

    Lyophilized from 0.22 μm filtered solution in 50 mM Tris, 150 mM NaCl, pH7.5. Normally trehalose is added as protectant before lyophilization.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • Background
    Protein S (PROS1) is glycoprotein and expressed in many cell types supporting its reported involvement in multiple biological processes that include coagulation, apoptosis, cancer development and progression, and the innate immune response. Known receptors bind S1 are ACE2, angiotensin-converting enzyme 2, DPP4, CEACAM etc.. It's been reported that 2019-nCoV can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor. The spike protein is a large type I transmembrane protein containing two subunits, S1 and S2. S1 mainly contains a receptor binding domain (RBD), which is responsible for recognizing the cell surface receptor. S2 contains basic elements needed for the membrane fusion.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity.
  • References
  • Please contact us via TechSupport@acrobiosystems.com if you have any question on this product.

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Price(USD) : $400.00

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