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Your Position: Home > All Other Proteins > TRAIL R2 > TR2-C52H7

Cynomolgus TRAIL R2 / DR5 / TNFRSF10B Protein, His Tag

  • Synonym
    TNFRSF10B,TRAILR2,TRAIL-R2,CD262,DR5,KILLER,TRICK2,ZTNFR9,TRICKB
  • Source
    Cynomolgus TRAIL R2, His Tag (TR2-C52H7) is expressed from human 293 cells (HEK293). It contains AA Ile 58 - Ser 212 (Accession # A0A2K5TXK0-1).
    Predicted N-terminus: Ile 58
  • Molecular Characterization
    Online(Ile 58 - Ser 212) A0A2K5TXK0-1

    This protein carries a polyhistidine tag at the C-terminus.

    The protein has a calculated MW of 19.1 kDa. The protein migrates as 25-30 kDa under reducing (R) condition (SDS-PAGE) due to Glycosylation.

  • Endotoxin
    Less than 1.0 EU per μg by the LAL method.
  • Purity

    >90% as determined by SDS-PAGE.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
SDS-PAGE
Cynomolgus TRAIL R2, His Tag (Cat. No. TR2-C52H7) SDS-PAGE gel

Cynomolgus TRAIL R2, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 90%.

Bioactivity-ELISA
Cynomolgus TRAIL R2, His TagCynomolgus TRAIL R2, His Tag (Cat. No. TR2-C52H7) ELISA bioactivity

Immobilized Cynomolgus TRAIL R2, His Tag (Cat. No. TR2-C52H7) at 5 μg/mL (100 μL/well) can bind Human TRAIL, Mouse IgG2a Fc Tag (Cat. No. TRL-H5259) with a linear range of 1-20 ng/mL (QC tested).

  • Background
    Tumor necrosis factor receptor superfamily member 10B (TNFRSF10B) is also known as TNF-related apoptosis-inducing ligand receptor 2 (TRAILR2), Death receptor 5 (DR5), CD262, KILLER, is a member of the TNF-receptor superfamily, and contains an intracellular death domain. TNFRSF10B / DR-5 is widely expressed in adult and fetal tissues; very highly expressed in tumor cell lines. TRAILR2 / CD262 / DR5 is the receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD (a death domain containing adaptor protein) of TRAIL-R2 / TNFRSF10B recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. CD262 / DR5 Promotes the activation of NF-kappa-B. DR5 is essential for ER stress-induced apoptosis and is regulated by p53/TP53.
  • References
    • Please contact us via TechSupport@acrobiosystems.com if you have any question on this product.

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    Price(USD) : $260.00

    Price(USD) : $1600.00

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