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Your Position: Home > All Other Proteins > Integrin alpha L beta 2 > IT2-H52W6

Human Integrin alpha L beta 2 (ITGAL&ITGB2) Heterodimer Protein, His Tag&Tag Free

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  • Synonym
    Integrin alpha L beta 2,ITGAL&ITGB2
  • Source
    Human ITGAL&ITGB2 Heterodimer Protein, His Tag&Tag Free (IT2-H52W6) is expressed from human 293 cells (HEK293). It contains AA Tyr 26 - Met 1089 (ITGAL) & Gln 23 - Asn 700 (ITGB2) (Accession # P20701-1(ITGAL) & P05107-1(ITGB2)).
  • Molecular Characterization
    Online-Res(Tyr 26 - Met 1089 (ITGAL) & Gln 23 - Asn 700 (ITGB2)) P20701-1 (ITGAL) & P05107-1 (ITGB2)

    Human ITGAL & ITGB2 Heterodimer Protein, produced by co-expression of ITGAL and ITGB2, has a calculated MW of 124.2 kDa (ITGAL) & 80.1 kDa (ITGB2). Subunit ITGAL is fused with an acidic tail at the C-terminus and followed by a polyhistidine tag and subunit ITGB2 contains no tag but a basic tail at the C-terminus.

  • Endotoxin
  • Formulation

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  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • Background
    Integrin alpha-L beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrin alpha L beta 2 is also a receptor for F11R (By similarity). Involved in a variety of immune phenomena including leukocyte-endothelial cell interaction, cytotoxic T-cell mediated killing, and antibody dependent killing by granulocytes and monocytes. Contributes to natural killer cell cytotoxicity. Involved in leukocyte adhesion and transmigration of leukocytes including T-cells and neutrophils. Required for generation of common lymphoid progenitor cells in bone marrow, indicating the role in lymphopoiesis. Integrin alpha L beta 2 in association with ICAM3, contributes to apoptotic neutrophil phagocytosis by macrophages.
  • References
      
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Price(USD) : $410.00

Price(USD) : $2880.00

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  • Number of Launched Drugs:1 Details
  • Number of Drugs in Clinical Trials:0 Details
  • Latest Research Phase:Approved

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