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Your Position: Home > All Other Proteins > Integrin alpha D beta 2 > IT2-H52W5

Human Integrin alpha D beta 2 (ITGAD&ITGB2) Heterodimer Protein, His Tag&Tag Free

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  • Synonym
    Integrin alpha D beta 2,ITGAD & ITGB2
  • Source
    Human ITGAD&ITGB2 Heterodimer Protein, His Tag&Tag Free (IT2-H52W5) is expressed from human 293 cells (HEK293). It contains AA Phe 18 - Asn 1099 (ITGAD) & Gln 23 - Asn 700 (ITGB2) (Accession # Q13349-1(ITGAD) & P05107-1(ITGB2)).
  • Molecular Characterization
    Online-Res(Phe 18 - Asn 1099 (ITGAD) & Gln 23 - Asn 700 (ITGB2)) Q13349-1 (ITGAD) & P05107-1 (ITGB2)

    Human ITGAD & ITGB2 Heterodimer Protein, produced by co-expression of ITGAD and ITGB2, has a calculated MW of 125 kDa (ITGAD) & 80.1 kDa (ITGB2). Subunit ITGAD is fused with an acidic tail at the C-terminus and followed by a polyhistidine tag and subunit ITGB2 contains no tag but a basic tail at the C-terminus.

  • Endotoxin
  • Formulation

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  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • Background
    Integrin alpha-D/beta-2 is a receptor for ICAM3 and VCAM1. May play a role in the atherosclerotic process such as clearing lipoproteins from plaques and in phagocytosis of blood-borne pathogens, particulate matter, and senescent erythrocytes from the blood. Contributes to natural killer cell cytotoxicity. Involved in leukocyte adhesion and transmigration of leukocytes including T-cells and neutrophils. Triggers neutrophil transmigration during lung injury through PTK2B/PYK2-mediated activation (PubMed:18587400). Alpha D beta 2, selectively binds ICAM-3 and does not appear to bind ICAM-1. In addition, a soluble form of alpha D beta 2 binds VCAM-1 with greater efficiency relative to ICAM-3. The I domain of alpha D contains a binding site for VCAM-1 since recombinant alpha D I domain binds specifically to VCAM-1.
  • References
      
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Price(USD) : $410.00

Price(USD) : $2880.00

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