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Human Angiopoietin-like protein 2 / ANGPTL2 Protein, His Tag

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  • Synonym
    Angiopoietin-like Protein 2,ANGPTL2,ARP2,Angiopoietin-related protein 2
  • Source
    Human Angiopoietin-like protein 2, His Tag (AN2-H52H5) is expressed from human 293 cells (HEK293). It contains AA Gln 23 - His 493 (Accession # Q9UKU9-1).
    Predicted N-terminus: Gln 23
  • Molecular Characterization
    Online-Res(Gln 23 - His 493) Q9UKU9-1

    This protein carries a polyhistidine tag at the C-terminus.

    The protein has a calculated MW of 56.7 kDa.

  • Endotoxin
  • Formulation

    Please contact us for detailed information.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • Background
    Angiopoietin-like Protein 2 (ANGPTL2), also known as ARP2 is a secreted glycoprotein that contains a N-terminal coiled coil domain and a C-terminal fibrinogen like domain. ANGPTL2 has both pro and anti-angiogenic functions. It serves as tumor suppressor in ovarian cancer, and also promote metastasis in various cancer types, making it potential biomarker for tumor progression. ANGPTL2 also function as growth factor to enhance the survival of hematopoietic progenitors, mediated by its coiled coil domain. Receptor of ANGPTL2 is recently identified as LILRB2, and both the coiled coil domain and fibrinogen like domain are required for optimal binding.
  • Clinical and Translational Updates
  • Please contact us via TechSupport@acrobiosystems.com if you have any question on this product.

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