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Your Position: Home > Other Recombinant Proteins > GFR alpha-2 > Human GFRA2 /GDNFRB Protein

Human GFR alpha-2 Protein

  • Synonym
    GFRA2,GDNFRB,NRTNR-ALPHA,NTNRA,RETL2,TRNR2
  • Source
    Human GFR alpha-2, His Tag (GF2-H5225) is expressed from human 293 cells (HEK293). It contains AA Ser 22 - Ser 441 (Accession # NP_001486.4).
    Predicted N-terminus: Ser 22
  • Molecular Characterization
    GFR alpha-2(Ser 22 - Ser 441) NP_001486.4

    This protein carries a polyhistidine tag at the C-terminus.

    The protein has a calculated MW of 47.6 kDa. The protein migrates as 60-70 KDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin
    Less than 1.0 EU per μg by the LAL method.
  • Purity

    >97% as determined by SDS-PAGE.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    No activity loss is observed after storage at:

    1. 4-8°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
SDS-PAGE
Human GFR alpha-2, His Tag (Cat. No. GF2-H5225) SDS-PAGE gel

Human GFR alpha-2, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 97%.

  • Background
    GDNF family receptor alpha-2 (GFRA2) is also known as GDNF receptor beta, Neurturin receptor alpha, RET ligand 2, TGF-beta-related neurotrophic factor receptor 2, is a cell membrane protein which belongs to the GDNFR family. Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. GDNF is a glycosylated, disulfide-bonded homodimer that is distantly related to the TGF-beta superfamily of growth factors. Three receptors for these factors, GFRα-1, GFRα-2 and GFRα-3 have been identified. The isoform 1 of GFRA2 is found in both brain and placenta. GFRA2 mediates the NRTN-induced autophosphorylation and activation of the RET receptor and also able to mediate GDNF signaling through the RET tyrosine kinase receptor. GFRA2 mediates the NRTN-induced autophosphorylation and activation of the RET receptor. It can also mediate GDNF signaling through the RET tyrosine kinase receptor.
  • References
  • Please contact us via TechSupport@acrobiosystems.com if you have any question on this product.

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