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Your Position: Home > All Other Proteins > CD73 > CD3-C52H5

Canine CD73 / NT5E Protein, His Tag

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  • Synonym
    CD73,NT5E,5'-Nucleotidase,5'-NT,NT5,NTE
  • Source
    Canine CD73, His Tag (CD3-C52H5) is expressed from human 293 cells (HEK293). It contains AA Trp 27 - Ser 549 (Accession # XP_038540011.1).
    Predicted N-terminus: Trp 27
  • Molecular Characterization
    Online-Res(Trp 27 - Ser 549) XP_038540011.1

    This protein carries a polyhistidine tag at the C-terminus.

    The protein has a calculated MW of 59.8 kDa.

  • Endotoxin
  • Formulation

    Please contact us for detailed information.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • Background
    5'-nucleotidase (5'-NT), also known as ecto-5'-nucleotidase or CD73 (cluster of differentiation 73), is an enzyme that is encoded by the NT5E gene. CD73 commonly serves to convert AMP to adenosine. Ecto-5-prime-nucleotidase (5-prime-ribonucleotide phosphohydrolase) catalyzes the conversion at neutral pH of purine 5-prime mononucleotides to nucleosides, the preferred substrate being AMP. Other forms of 5-prime nucleotidase exist in the cytoplasm and lysosomes and can be distinguished from ecto-NT5 by their substrate affinities, requirement for divalent magnesium ion, activation by ATP, and inhibition by inorganic phosphate. Rare allelic variants are associated with a syndrome of adult-onset calcification of joints and arteries (CALJA) affecting the iliac, femoral, and tibial arteries reducing circulation in the legs and the joints of the hands and feet causing pain.
  • Research Progress of CD73
      
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Price(USD) : $350.00

Price(USD) : $2310.00

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  • Number of Drugs in Clinical Trials:8 Details
  • Latest Research Phase:Phase 2 Clinical

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