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Cynomolgus Integrin isoform alpha-7X1B beta 1 (ITGA7X1B&ITGB1) Heterodimer Protein, Tag Free&His Tag

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  • Synonym
    integrin alpha-7 isoform X1 beta 1,ITGA7X1&ITGB1,ITGA7X1B1
  • Source
    Cynomolgus ITGA7X1B&ITGB1 Heterodimer Protein, Tag Free&His Tag (IT1-C52W3) is expressed from human 293 cells (HEK293). It contains AA Phe 34 - Pro 1041 (ITGA7X1B) & Gln 21 - Asp 728 (ITGB1) (Accession # XP_005571182.1(ITGA7X1B) & A0A2K5WHU8-1(ITGB1)).
    Predicted N-terminus: Phe 34 (ITGA7X1B) & Gln 21 (ITGB1)
  • Molecular Characterization
    Online-Res(Phe 34 - Pro 1041 (ITGA7X1B) & Gln 21 - Asp 728 (ITGB1)) XP_005571182.1 (ITGA7X1B) & A0A2K5WHU8-1 (ITGB1)

    Cynomolgus ITGA7X1B&ITGB1 Heterodimer Protein, Tag Free&His Tag, produced by co-expression of ITGA7X1B and ITGB1, has a calculated MW of 116.5 kDa (ITGA7X1B) and 82 kDa (ITGB1). Subunit ITGA7X1B contains no tag but an acidic tail at the C-terminus and subunit ITGB1 contains his tag and a basic tail at the C-terminus.

  • Endotoxin
  • Formulation

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  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • Background
    Integrin alpha-7/beta-1 is the primary laminin receptor on skeletal myoblasts and adult myofibers, which is highly expressed in cardiac muscle, skeletal muscle and smooth muscle cells, and localizes to Z-disc and costamere structures. It is involved in the maintenance of the myofibers cytoarchitecture as well as for their anchorage, viability and functional integrity. Isoform Alpha-7X2B and isoform Alpha-7X1B promote myoblast migration on laminin 1 and laminin 2/4, but isoform Alpha-7X1B is less active on laminin 1 (In vitro). ITGA7 has been shown to interact with Merosin, ITGB1, FHL2 and FHL3.
  • Clinical and Translational Updates
      
  • Please contact us via TechSupport@acrobiosystems.com if you have any question on this product.

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Price(USD) : $410.00

Price(USD) : $2880.00

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