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Your Position: Home > CAR-T > DLL3 > DL3-H82F5

Biotinylated Human DLL3 Protein, Fc,Avitag™ (MALS verified)

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Based on the high binding affinity between biotin-streptavidin systems, our Streptavidin series products are recommended to use together with biotinylated proteins to get lower non-specific binding results in a shorter time.
  • Synonym
    Delta3,delta-like 3 (Drosophila),delta-like protein 3,DLL3,Pudgy,SCDO1,SCDO1delta3
  • Source
    Biotinylated Human DLL3, Fc,Avitag(DL3-H82F5) is expressed from human 293 cells (HEK293). It contains AA Ala 27 - Leu 492 (Accession # Q9NYJ7-1 ).
    Predicted N-terminus: Ala 27
  • Molecular Characterization
    DLL3 Structure

    This protein carries a human IgG1 Fc tag at the C-terminus, followed by a Avi tag (Avitag™)

    The protein has a calculated MW of 76.7 kDa. The protein migrates as 60-65 kDa under reducing (R) condition (SDS-PAGE).

  • Labeling
    Biotinylation of this product is performed using Avitag™ technology. Briefly, the single lysine residue in the Avitag is enzymatically labeled with biotin.
  • Protein Ratio
    Passed as determined by the HABA assay / binding ELISA.
  • Endotoxin
    Less than 1.0 EU per μg by the LAL method.
  • Purity

    >95% as determined by SDS-PAGE.

    >90% as determined by SEC-MALS.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in 50 mM Tris, 100 mM Glycine, 25 mM Arginine, 150 mM NaCl, pH7.5 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
SDS-PAGE
DLL3 SDS-PAGE

Biotinylated Human DLL3, Fc,Avitag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.

SEC-MALS
DLL3 MALS images

The purity of Biotinylated Human DLL3, Fc,Avitag(Cat. No. DL3-H82F5) is more than 90% and the molecular weight of this protein is around 100-120 kDa verified by SEC-MALS.

Bioactivity-ELISA
 DLL3 ELISA

Immobilized Anti-DLL3 Antibody (specific Binding DSL of DLL3), Human IgG1 at 1 μg/mL (100 μL/well) can bind Biotinylated Human DLL3, Fc,Avitag (Cat. No. DL3-H82F5) with a linear range of 0.1-13 ng/mL (QC tested).

  • Background
    Delta-like protein 3 (DLL3) is a transmembrane protein that belongs to the Delta/Serrate/Lag-2 (DSL) family of Notch ligands.May be required to divert neurons along a specific differentiation pathway. Plays a role in the formation of somite boundaries during segmentation of the paraxial mesoderm. DLL3 protein is expressed on the surface of tumor cells but not in normal adult tissues.
  • Clinical and Translational Updates
  • Please contact us via TechSupport@acrobiosystems.com if you have any question on this product.

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