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Your Position: Home > ADC > MMAE > MME-M5252

Mouse Anti-MMAE Antibody, Mouse IgG1 (MALS verified)

  • Source
    Mouse Anti-MMAE Antibody, Mouse IgG1 is a chimeric monoclonal antibody recombinantly expressed from human 293 cells (HEK293), which combines the variable region of a mouse monoclonal antibody with human IgG1 constant domain. The mouse monoclonal antibody is produced from a hybridoma resulting from fusion of SP2/0 myeloma and B-lymphocytes obtained from a mouse immunized with MMAE.
  • Isotype
    Mouse IgG1 / kappa
  • Specificity
    This product is a specific antibody specifically reacts with Specifically recognizes the target-MMAE.
  • Application
    This Monoclonal anti-MMAE antibody is designed for use in ELISA and PK environment.
  • Purity

    >95% as determined by SDS-PAGE.

    >90% as determined by SEC-MALS.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. This product is stable after storage at:
    2. -20°C to -70°C for 24 months in lyophilized state;
    3. -70°C for 12 months under sterile conditions after reconstitution.
SDS-PAGE
MMAE SDS-PAGE

Mouse Anti-MMAE Antibody, Mouse IgG1 on SDS-PAGE under reducing (R) and non-reducing (NR) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.

SEC-MALS
MMAE MALS images

The purity of Mouse Anti-MMAE Antibody, Mouse IgG1(Cat. No. MME-M5252) is more than 90% and the molecular weight of this protein is around 134-163 kDa verified by SEC-MALS.

Bioactivity-Elisa
 MMAE ELISA

Immobilized Disitamab Vedotin (RC48) at 0.2 μg/mL (100 μL/well) can bind Mouse Anti-MMAE Antibody, Mouse IgG1 (Cat. No. MME-M5252) with a linear range of 0.1-2 ng/mL (QC tested).

  • Background
    Monomethyl auristatin E (MMAE) is a synthetic derivative of dolastatin 10 and functions as a potent mitotic inhibitor by inhibiting tubulin polymerization. MMAE is widely used as a cytotoxic component of antibody-drug conjugates (ADCs) to treat several different cancer types. Anti-MMAE antibody is a Mouse monoclonal antibody. This antibody has been shown to work in applications such as: PK, PD, Immunoassay and ELISA.
  • Clinical and Translational Updates
  • Please contact us via TechSupport@acrobiosystems.com if you have any question on this product.

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ETD of in-stock products: 2 business days

Price(USD) : $300.00

Price(USD) : $1980.00

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