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Your Position: Home > Cytokines > TNFSF11 > RAL-H5217

ActiveMax® Human TNFSF11 / RANKL / CD254 Protein, Tag Free (MALS verified)

  • Synonym
    RANKL,CD254,TRANCE,OPGL,ODF
  • Source
    ActiveMax® Human TNFSF11, Tag Free(RAL-H5217) is expressed from human 293 cells (HEK293). It contains AA Gly 64 - Asp 245 (Accession # AAC51762.1 ).
    Predicted N-terminus: Gly
  • Molecular Characterization
    TNFSF11 Structure

    This protein carries no "tag"

    The protein has a calculated MW of 20.5 kDa. The protein migrates as 28-33 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin
    Less than 0.1 EU per μg by the LAL method.
  • Sterility
    The sterility testing was performed by membrane filtration method.
  • Purity

    >95% as determined by SDS-PAGE.

    >95% as determined by SEC-MALS.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
SDS-PAGE
TNFSF11 SDS-PAGE

ActiveMax® Human TNFSF11, Tag Free on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.

SEC-MALS
TNFSF11 MALS images

The purity of ActiveMax® Human TNFSF11, Tag Free (Cat. No. RAL-H5217) is more than 95% and the molecular weight of this protein is around 70-90 kDa verified by SEC-MALS.

Bioactivity-ELISA
 TNFSF11 ELISA

Immobilized Human TNFSF11, Tag Free (Cat. No. RAL-H5217) at 2 μg/mL (100 μL/well) can bind Human RANK, Mouse IgG2a Fc Tag, low endotoxin (Cat. No. RAK-H5251) with a linear range of 0.1-4 ng/mL (QC tested).

 TNFSF11 ELISA

Immobilized Human TNFSF11, Tag Free (Cat. No. RAL-H5217) at 2 μg/mL (100 μL/well) can bind Human Osteoprotegerin, His Tag (Cat. No. TNB-H5220) with a linear range of 0.01-0.313 μg/mL (Routinely tested).

 TNFSF11 ELISA

Immobilized Human TNFSF11, Tag Free (Cat. No. RAL-H5217) at 2 μg/mL (100 μL/well) can bind Anti-TNFSF11 Antibody, Human IgG1 with a linear range of 0.1-4 ng/mL (Routinely tested).

  • Background
    Receptor activator of nuclear factor kappa-B ligand (RANKL), also known as tumor necrosis factor ligand superfamily member 11 (TNFSF11), TNF-related activation-induced cytokine (TRANCE), osteoprotegerin ligand (OPGL), and osteoclast differentiation factor (ODF), is known as a type II membrane protein and is a member of the tumor necrosis factor (TNF) superfamily. RANKL, through its ability to stimulate osteoclast formation and activity, is a critical mediator of bone resorption and overall bone density. Some findings also suggestion some cancer cells, particularly prostate cancer cells, can activate an increase in bone remodeling and ultimately increase overall bone production.[17] This increase in bone remodeling and bone production increases the overall growth of bone metastasizes. The overall control of bone remodeling is regulated by the binding of RANKL with its receptor or its decoy receptor, respectively, RANK and OPG.
  • Clinical and Translational Updates
  • Please contact us via TechSupport@acrobiosystems.com if you have any question on this product.

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