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Your Position: Home > Neutralization Reagents > Spike protein > CMO-PAN001

SARS-CoV-2 (WT) Pseudovirus Neutralization Reagents

For research use only.
Materials Provided
IDComponentsSize
CMO-PAN001-C01 SARS-CoV-2 Spike (WT) Fluc-GFP Pseudovirus 96 Tests
CMO-PAN001-C02 HEK293/Human ACE2 Overexpression Stable Cell Line 1 Vial
CMO-PAN001-C03 Anti-SARS-CoV-2 Spike RBD Neutralizing Antibody, Chimeric mAb, Human IgG1 (AM122) 100 ug
  • Background

    The reagents provided are powerful tools for in vitro screening and characterization of serum, antibodies, and drugs to neutralize the infectivity of SARS-CoV-2 spike protein.

    1. SARS-CoV-2 Spike (WT) Fluc-GFP Pseudovirus is derived from pseudotyped HIV-1 virus expressing SARS-CoV-2 spike protein. It contains firefly luciferase gene for chemiluminescence detection and green fluorescent protein (GFP) reporter gene. The pseudovirus can effectively infect human ACE2 overexpressing cells.
    2. HEK293/Human ACE2 Overexpression Stable Cell Line is a stably transfected HEK293 cell line which stably overexpress human angiotensin I converting enzyme 2 (ACE2). Surface expression of ACE2 was confirmed by flow cytometry.

    3. Anti-SARS-CoV-2 Spike RBD Antibody, Chimeric mAb, Human IgG1 (AM122) is ideal as a positive control in SARS-CoV-2 (WT) Pseudovirus Neutralization Assay.

Notice

a. Though pseudovirus particles has no pathogenicity and cannot replicate, the assays should be carried out carefully in a Biosafety Level 2 or higher-level laboratory with a biosafety cabinet.

b. Serum samples from animals or humans should be inactivated in a water bath at 56 °C for 30 min before being tested.

c. Please avoid freezing and thawing, which would influence the titer of the pseudovirus.

d. The RLU could be influenced by multi-factors. If the detection reagent or luminescence meter other than those in this protocol is used, a pre-test should be carried out to determine an appropriate virus dosage per well.

e. The product is for Research Use Only.

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