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Your Position: Home > All Other Proteins > MSR1 > Human MSR1 / CD204 Protein, His Tag

Human MSR1 / CD204 Protein, His Tag

  • Synonym
    MSR1,CD204,SCARA1,SR-A,phSR1,phSR2
  • Source
    Human MSR1, His Tag (MS1-H5226) is expressed from human 293 cells (HEK293). It contains AA Lys 77 - Leu 451 (Accession # NP_619729).
    Predicted N-terminus: Lys 77
  • Molecular Characterization
    Online( Lys 77 - Leu 451) NP_619729

    This protein carries a polyhistidine tag at the C-terminus.

    The protein has a calculated MW of 42.1 kDa. The protein migrates as 65-72 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin
    Less than 1.0 EU per μg by the LAL method.
  • Purity

    >95% as determined by SDS-PAGE.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    No activity loss was observed after storage at:

    1. 4-8°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
SDS-PAGE
Human MSR1, His Tag (Cat. No. MS1-H5226) SDS-PAGE gel

Human MSR1, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.

  • Background
    Macrophage scavenger receptor 1 (MSR1) is also known as CD204, SCARA1, SR-A, and is class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing of this gene. These receptors or isoforms are trimeric integral membrane glycoproteins and have been implicated in many macrophage-associated physiological and pathological processes. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. Defects in MSR1 may be a cause of prostate cancer (PC) or Barrett esophagus (BE).
  • References
  • Please contact us via TechSupport@acrobiosystems.com if you have any question on this product.

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