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Your Position: Home > Enzyme > MMP-9 > MM9-M52H9

Mouse MMP-9 Protein, His Tag

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  • Synonym
    MMP9,CLG4B,GELB,MANDP2,Gelatinase B
  • Source
    Mouse MMP-9, His Tag (MM9-M52H9) is expressed from human 293 cells (HEK293). It contains AA Ala 20 - Pro 730 (Accession # P41245-1). It needs to be activated by agents such as APMA in vitro to have hydrolytic activity.
    Predicted N-terminus: Ala 20
  • Molecular Characterization
    Online-Res(Ala 20 - Pro 730) P41245-1

    This protein carries a polyhistidine tag at the C-terminus.

    The protein has a calculated MW of 80.4 Kda.

  • Endotoxin
  • Formulation

    Please contact us for detailed information.

    Contact us for customized product form or formulation.

  • Storage

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. The product MUST be stored at -70°C or lower upon receipt;
    2. -70°C for 3 months under sterile conditions.
  • Shipping
    This product is supplied and shipped as sterile liquid solution with dry ice, please inquire the shipping cost.
  • Background
    Matrix metallopeptidase 9 (MMP-9) is also known as 92 kDa type IV collagenase, 92 kDa gelatinase or gelatinase B (GELB), CLG4B, is secreted from neutrophils, macrophages, and a number of transformed cells, and is the most complex family member in terms of domain structure and regulation of its activity. . Structurally, MMP9 maybe be divided into five distinct domains: a prodomain which is cleaved upon activation, a gelatinbinding domain consisting of three contiguous fibronectin type II units, a catalytic domain containing the zinc binding site, a prolinerich linker region, and a carboxyl terminal hemopexinlike domain. This enzyme degrades various substrates including gelatin, collagen types IV and V, and elastin. MMP9 is involved in a variety of autoimmune diseases such as systemic lupus erythematosus, rheumatoid arthritis, and multiple sclerosis, and be regarded as a potential therapeutic target.
  • Clinical and Translational Updates
      
  • Please contact us via TechSupport@acrobiosystems.com if you have any question on this product.

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Price(USD) : $350.00

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Drug Development Status

  • Number of Launched Drugs:0 Details
  • Number of Drugs in Clinical Trials:3 Details
  • Latest Research Phase:Phase 1 Clinical

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