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Your Position: Home > Enzyme > MMP-8 > MM8-M52H8

Mouse MMP-8 Protein, His Tag (active enzyme, MALS verified)

  • Synonym
    CLG1 Protein, HNC Protein, MMP-8 Protein, PMNL-CL Protein,
  • Source
    Mouse MMP-8, His Tag(MM8-M52H8) is expressed from human 293 cells (HEK293). It contains AA Phe 21 - Ser 465 (Accession # O70138-1 ).
    Predicted N-terminus: Phe 21
  • Molecular Characterization
    MMP-8 Structure

    This protein carries a polyhistidine tag at the C-terminus

    The protein has a calculated MW of 52.7 Kda. The protein migrates as 63-68 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin
    Less than 1.0 EU per μg by the LAL method.
  • Purity

    >90% as determined by SDS-PAGE.

    >90% as determined by SEC-MALS.

  • Formulation

    Supplied as 0.2 μm filtered solution in 20 mM MES,150 mM NaCl,0.05% Brij-35, pH6.0 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. The product MUST be stored at -70°C or lower upon receipt;
    2. -70°C for 3 months under sterile conditions.
SDS-PAGE
MMP-8 SDS-PAGE

Mouse MMP-8, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 90%.

SEC-MALS
MMP-8 MALS images

The purity of Mouse MMP-8, His Tag(Cat. No. MM8-M52H8) is more than 90% and the molecular weight of this protein is around 58-73 kDa verified by SEC-MALS.

Bioactivity

Measured by its ability to cleave a fluorogenic peptide substrate Mca-KPLGL-Dpa-AR-NH2,The specific activity is >400 pmol/min/μg(QC test)

  • Background
    Matrix metalloproteinase-8(MMP-8)also known as neutrophil collagenase and CLG1,is a member of matrix metalloproteinases (MMPs) family,which degrade components of the extracellular matrix (ECM) and play essential roles in various physiological processes as well as pathological processes. MMP-8 may affect the metastatic behavior of breast cancer cells through protection against lymph node metastasis, underlining the importance of anti-target identification in drug development. MMP-8 in the tumor may have a protective effect against lymph node metastasis.
  • Clinical and Translational Updates
  • Please contact us via TechSupport@acrobiosystems.com if you have any question on this product.

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Price(USD) : $350.00

Price(USD) : $2160.00

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Drug Development Status

  • Number of Launched Drugs:0 Details
  • Number of Drugs in Clinical Trials:0 Details
  • Latest Research Phase:Discontinued

Datasheet & Documentation

Request for DMF
DMF (Drug Master File)

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