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Your Position: Home > Others > EphA2 > EP2-H52H4

Human EphA2 Protein, His Tag (MALS verified)

  • Synonym
    EphA2
  • Source
    Human EphA2 Protein, His Tag (EP2-H52H4) is expressed from human 293 cells (HEK293). It contains AA Ala 24 - Asn 534 (Accession # P29317-1).
    Predicted N-terminus: Ala 24
  • Molecular Characterization
    Online(Ala 24 - Asn 534) P29317-1

    This protein carries a polyhistidine tag at the C-terminus.

    The protein has a calculated MW of 58.1 kDa. The protein migrates as 60-65 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin
    Less than 1.0 EU per μg by the LAL method.
  • Purity

    >95% as determined by SDS-PAGE.

    >90% as determined by SEC-MALS.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
SDS-PAGE
Human EphA2 Protein, His Tag (Cat. No. EP2-H52H4) SDS-PAGE gel

Human EphA2 Protein, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.

SEC-MALS
Human EphA2 Protein, His Tag (Cat. No. ) MALS images

The purity of Human EphA2 Protein, His Tag (Cat. No. EP2-H52H4) is more than 90% and the molecular weight of this protein is around 55-75 kDa verified by SEC-MALS.

  • Background
    Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Activated by the ligand ephrin-A1/EFNA1 regulates migration, integrin-mediated adhesion, proliferation and differentiation of cells. Regulates cell adhesion and differentiation through DSG1/desmoglein-1 and inhibition of the ERK1/ERK2 (MAPK3/MAPK1, respectively) signaling pathway. Engaged by the ligand ephrin-A5/EFNA5 may regulate lens fiber cells shape and interactions and be important for lens transparency development and maintenance. With ephrin-A2/EFNA2 may play a role in bone remodeling through regulation of osteoclastogenesis and osteoblastogenesis.
  • Clinical and Translational Updates
      
  • Please contact us via TechSupport@acrobiosystems.com if you have any question on this product.

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