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Your Position: Home > All Other Proteins > Siglec-7 | J chain > SI7-H5259

Human Siglec-7&J chain Pentamer Protein, IgM Fc Tag&His Tag

This product is still under development. Please contact us if you have interest in this product. We will accelerate the development process accordingly and reserve this product for you as request.
  • Synonym
    CDw328,D-siglec,A79 membrane protein,p75,Adhesion inhibitory receptor molecule 1, AIRM-1
  • Source
    Human Siglec-7&J chain Pentamer, IgM Fc Tag&His Tag (SI7-H5259) is expressed from human 293 cells (HEK293). It contains AA Gln 19 - Leu 353 (Siglec-7) & Gln 23 - Asp 159 (J chain) (Accession # Q9Y286-1(Siglec-7) & P01591(J chain)).
    Predicted N-terminus: Gln 19 (Siglec-7) & Gln 23 (J chain)
  • Molecular Characterization

    Human Siglec-7 & J chain Heterohexamer Protein, Human IgM Fc Tag & His Tag, produced by co-expression of Siglec-7 and J chain, has a calculated MW of 75.7 kDa (Siglec-7) and 17.5 kDa (J chain). Subunit Siglec-7 is fused with a Human IgM Fc tag at the C-terminus which self-assembles to homopentamer, and subunit Joining chain (J chain) is fused with a polyhistidine tag at the C-terminus.

  • Endotoxin
  • Formulation

    Please contact us for detailed information.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • Background
    Siglec-7 is a member of the human CD33‐related Siglec receptor. The extracellular region of Siglec‐7 is characterized by an N‐terminal V‐set Ig domain that can bind sialic acid and two C2‐set Ig domains. The cytoplasmic tail of Siglec‐7 has one immune‐receptor tyrosine‐based inhibitory motif (ITIM) and one ITIM‐like motif. Siglec-7 is considered as a sialic acid-dependent immunoreceptor with inhibitory potential and expressed predominantly on human NK cells, monocytes and a small subset of CD8+ T cells.
  • Clinical and Translational Updates
      
  • Please contact us via TechSupport@acrobiosystems.com if you have any question on this product.

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Price(USD) : $700.00

Price(USD) : $6000.00

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