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Your Position: Home > Others > IDE > IDE-H51W3

Human IDE Protein, Twin-Strep Tag

This product is still under development. Please contact us if you have interest in this product. We will accelerate the development process accordingly and reserve this product for you as request.
  • Synonym
    IDE, insulin degrading enzyme
  • Source
    Human IDE Protein, Twin-Strep Tag (IDE-H51W3) is expressed from E.coli cells. It contains AA Met 42 - Leu 1019 (Accession # P14735).
    Predicted N-terminus: Met 42
  • Molecular Characterization
    Online-Res(Met 42 - Leu 1019) P14735

    The protein has a calculated MW of 116.5 kDa.

  • Endotoxin
    Less than 1.0 EU per μg by the LAL method.
  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 . Normally trehalose is added as protectant before lyophilization.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • Background
    Insulin-degrading enzyme, also known alternatively as IDE, insulysin or insulin protease, is a large zinc-binding protease of the M16 metalloprotease family known to be responsible for insulin degradation. In addition to insulin, IDE degrades many targets including glucagon, atrial natriuretic peptide, and beta-amyloid peptide, regulates proteasomal degradation and other cell functions. IDE represents a pathophysiological link between type 2 diabetes (T2DM) and late onset Alzheimer's disease (AD). Potent and selective modulators of IDE activity are potential drugs for therapies of both diseases.
  • Clinical and Translational Updates
  • Please contact us via TechSupport@acrobiosystems.com if you have any question on this product.

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