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Your Position: Home > Aneuro > GRIN2B > GRB-H52H3

Human GRIN2B / NMDAR2B / GluN2B Protein, His Tag (MALS verified)

  • Synonym
    NMDAR2B
  • Source
    Human GRIN2B, His Tag (GRB-H52H3) is expressed from human 293 cells (HEK293). It contains AA Arg 27 - Met 394 (Accession # NP_000825.2).
    Predicted N-terminus: Arg 27
  • Molecular Characterization
    Online(Arg 27 - Met 394) NP_000825.2

    This protein carries a polyhistidine tag at the C-terminus.

    The protein has a calculated MW of 43.7 kDa. The protein migrates as 50-55 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin
    Less than 1.0 EU per μg by the LAL method.
  • Purity

    >95% as determined by SDS-PAGE.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
SDS-PAGE
Human GRIN2B, His Tag (Cat. No. GRB-H52H3) SDS-PAGE gel

Human GRIN2B, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.

SEC-MALS
Human GRIN2B, His Tag (Cat. No. ) MALS images

The purity of Human GRIN2B, His Tag (Cat. No. GRB-H52H3) is more than 85% and the molecular weight of this protein is around 45-55 kDa verified by SEC-MALS.

  • Background
    NMDA receptors (NMDARs) are members of the glutamate-gated ion-channel family that mediate a slow calcium-permeable component of excitatory synaptic transmission in the central nervous system. The NMDA receptors are heterotetramers of seven genetically encoded, differentially expressed subunits including NR1 (GRIN1), NR2 (GRIN2A, GRIN2B, GRIN2C, or GRIN2D) and NR3 (GRIN3A or GRIN3B). The early expression of this gene in development suggests a role in brain development, circuit formation, synaptic plasticity, and cellular migration and differentiation.
  • Clinical and Translational Updates
      
  • Please contact us via TechSupport@acrobiosystems.com if you have any question on this product.

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