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Your Position: Home > TME Relevant Pathway > Integrin alpha V beta 1 > IT1-R52E1

Rat Integrin alpha V beta 1 (ITGAV&ITGB1) Heterodimer Protein, His Tag&Tag Free

This product is still under development. Please contact us if you have interest in this product. We will accelerate the development process accordingly and reserve this product for you as request.
  • Synonym
    Integrin alpha V beta 1,ITGAV&ITGB1
  • Source
    Rat ITGAV&ITGB1 Heterodimer, His Tag&Tag Free(IT1-R52E1) is expressed from human 293 cells (HEK293). It contains AA Phe 31 - Pro 988 & Gln 21 - Asp 729 (Accession # NP_001385621.1 & P49134-1 ).
    Predicted N-terminus: Phe 31 | Gln 21
  • Molecular Characterization

    The protein has a calculated MW of 113 kDa | 83.7 kDa.

  • Endotoxin
    Less than 1.0 EU per μg by the LAL method.
  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • Background
    Integrin alpha-5/beta-1 is a receptor for ibrinogen. Integrin alpha-1/beta-1, alpha-2/beta-1, alpha-6/beta-1 and alpha-7/beta-1 are receptors for lamimin. Integrin alpha-4/beta-1 is a receptor for VCAM1. It recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-9/beta-1 is a receptor for VCAM1, cytotactin and osteopontin. It recognizes the sequence A-E-I-D-G-I-E-L in cytotactin. Integrin alpha-V/beta-1 is also a receptor for vitronectin. Beta-1 integrins recognize the sequence R-G-D in a wide array of ligands. Isoform 2 interferes with isoform 1 resulting in a dominant negative effect on cell adhesion and migration (in vitro). When associated with alpha-7/beta-1 integrin, regulates cell adhesion and laminin matrix deposition.
  • Clinical and Translational Updates

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Price(USD) : $410.00

Price(USD) : $2800.00

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Drug Development Status

  • Number of Launched Drugs:0 Details
  • Number of Drugs in Clinical Trials:4 Details
  • Latest Research Phase:Phase 2 Clinical

Datasheet & Documentation

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DMF (Drug Master File)

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